Multisystem inflammatory syndrome in adults (MIS-A)

Multisystem Inflammatory Syndrome in Adults

Multisystem Inflammatory Syndrome (MIS)

MIS-A

A rare syndrome found in adults with positive test results for SARS-CoV-2 by polymerase chain reaction or antibody assays indicating recent infection that is marked by cardiovascular, gastrointestinal, dermatologic, and neurologic symptoms without severe respiratory illness. The most common signs and symptoms that have been reported to date include fever, low blood pressure, abdominal pain, vomiting, diarrhea, neck pain, rash, chest pain, and tiredness not attributable to other infections.

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C178502

A patient aged greater than or equal to 21 y hospitalized for greater than or equal to 24 h, or with an illness resulting in death, who meets the following clinical and laboratory criteria. The patient should not have a more likely alternative diagnosis for the illness (e.g., bacterial sepsis, exacerbation of a chronic medical condition). I. Clinical Criteria: Subjective fever or documented fever (greater than or equal to 38.0 degrees C) for greater than or equal to 24 h prior to hospitalization or within the first 3 d of hospitalization* and at least 3 of the following clinical criteria occurring prior to hospitalization or within the first 3 d of hospitalization*. At least 1 must be a primary clinical criterion: A. Primary clinical criteria: 1. Severe cardiac illness includes myocarditis, pericarditis, coronary artery dilatation/aneurysm, or new-onset right or left ventricular dysfunction (LVEF less than 50%), 2nd/3rd degree AV block, or ventricular tachycardia. (Note: cardiac arrest alone does not meet this criterion) 2. Rash and nonpurulent conjunctivitis B. Secondary clinical criteria: 1. New-onset neurological signs and symptoms: includes encephalopathy in a patient without prior cognitive impairment, seizures, meningeal signs, or peripheral neuropathy (including Guillain-Barré syndrome) 2. Shock or hypotension not attributable to medical therapy (e.g., sedation, renal replacement therapy) 3. Abdominal pain, vomiting, or diarrhea 4. Thrombocytopenia (platelet count less than 150,000/microliter) II. Laboratory evidence: The presence of laboratory evidence of inflammation and SARS-CoV-2 infection. A. Elevated levels of at least 2 of the following: C-reactive protein, ferritin, IL-6, erythrocyte sedimentation rate, procalcitonin B. A positive SARS-CoV-2 test for current or recent infection by RT-PCR, serology, or antigen detection NOTE: *These criteria must be met by the end of hospital day 3, where the date of hospital admission is hospital day 0.

C178502

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191670

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191200

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177415

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179027

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191382

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C189083

ACC/AHA

SeroNet

A rare syndrome found in adults with positive test results for SARS-CoV-2 by polymerase chain reaction or antibody assays indicating recent infection that is marked by cardiovascular, gastrointestinal, dermatologic, and neurologic symptoms without severe respiratory illness. The most common signs and symptoms that have been reported to date include fever, low blood pressure, abdominal pain, vomiting, diarrhea, neck pain, rash, chest pain, and tiredness not attributable to other infections.

Multisystem inflammatory syndrome in adults (MIS-A)

Multisystem Inflammatory Syndrome in Adults

Multisystem Inflammatory Syndrome (MIS)

MIS-A

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17998

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49488

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49487

Multisystem Inflammatory Syndrome in Adults

CL1646825

Multisystem Inflammatory Syndrome in Adults

Thesaurus:C178502

Disease or Syndrome

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28193

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26726