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National Cancer Institute Thesaurus
| Preferred Name | Plerixafor | |
| Synonyms |
1,1'-[1,4-Phenylenebis(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane SDZ SID 791 AMD 3100 AMD3100 JM-3100 Mozobil PLERIXAFOR Plerixafor plerixafor |
|
| Definitions |
A bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1777 |
|
| Accepted_Therapeutic_Use_For |
Hematopoietic Stem Cell Mobilization
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|
| ALT_DEFINITION |
A drug used before autologous stem cell transplantation in patients with non-Hodgkin lymphoma or multiple myeloma. Plerixafor is given together with granulocyte-colony stimulating factor (G-CSF) to help move stem cells from the bone marrow to the blood. The stem cells can then be collected, stored, and given back to the patient. Plerixafor is a type of chemokine receptor antagonist.
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|
| CAS_Registry |
110078-46-1
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|
| Chemical_Formula |
C28H54N8
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|
| code |
C1777
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186329 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
|
| Contributing_Source |
CTRP FDA HemOnc PCDC
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|
| DEFINITION |
A bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation.
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|
| Display_Name |
Plerixafor
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|
| FDA_UNII_Code |
S915P5499N
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|
| FULL_SYN |
1,1'-[1,4-Phenylenebis(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane SDZ SID 791 AMD 3100 AMD3100 JM-3100 Mozobil PLERIXAFOR Plerixafor plerixafor
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|
| Has_Target | ||
| label |
Plerixafor
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|
| Legacy Concept Name |
AMD3100
|
|
| NCI_Drug_Dictionary_ID |
410786
|
|
| PDQ_Closed_Trial_Search_ID |
410786
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|
| PDQ_Open_Trial_Search_ID |
410786
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|
| Preferred_Name |
Plerixafor
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|
| prefixIRI |
Thesaurus:C1777
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0257001
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| subClassOf |
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