loading...| Preferred Name |
Plerixafor |
|
| Synonyms |
1,1'-[1,4-Phenylenebis(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane SDZ SID 791 AMD 3100 AMD3100 JM-3100 Mozobil PLERIXAFOR Plerixafor plerixafor |
|
| Definitions |
A bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1777 |
|
| Accepted_Therapeutic_Use_For |
Hematopoietic Stem Cell Mobilization |
|
| ALT_DEFINITION |
A drug used before autologous stem cell transplantation in patients with non-Hodgkin lymphoma or multiple myeloma. Plerixafor is given together with granulocyte-colony stimulating factor (G-CSF) to help move stem cells from the bone marrow to the blood. The stem cells can then be collected, stored, and given back to the patient. Plerixafor is a type of chemokine receptor antagonist. |
|
| CAS_Registry |
110078-46-1 |
|
| Chemical_Formula |
C28H54N8 |
|
| code |
C1777 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186329 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
|
| Contributing_Source |
CTRP FDA HemOnc PCDC |
|
| DEFINITION |
A bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation. |
|
| Display_Name |
Plerixafor |
|
| FDA_UNII_Code |
S915P5499N |
|
| FULL_SYN |
1,1'-[1,4-Phenylenebis(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane SDZ SID 791 AMD 3100 AMD3100 JM-3100 Mozobil PLERIXAFOR Plerixafor plerixafor |
|
| Has_Target | ||
| label |
Plerixafor |
|
| Legacy Concept Name |
AMD3100 |
|
| NCI_Drug_Dictionary_ID |
410786 |
|
| PDQ_Closed_Trial_Search_ID |
410786 |
|
| PDQ_Open_Trial_Search_ID |
410786 |
|
| Preferred_Name |
Plerixafor |
|
| prefixIRI |
Thesaurus:C1777 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0257001 |
|
| subClassOf |