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National Cancer Institute Thesaurus
| Preferred Name | Alirocumab | |
| Synonyms |
ALIROCUMAB Alirocumab Praluent |
|
| Definitions |
A human immunoglobulin G1 (IgG1) monoclonal antibody directed against human proprotein convertase subtilisin/kexin type 9 (PCSK9), that can be used in the treatment of hypercholesterolemia. Upon administration, alirocumab targets, binds to and inhibits the activity of PCSK9. This prevents the binding of PCSK9 to low-density lipoprotein receptor (LDLR) on hepatocytes and prevents its degradation. This increases LDLR on hepatocytes and increases the liver's ability to remove LDL cholesterol (LDL-C) from the blood, thereby lowering LDL-C levels. PCSK9 binds to LDLR on the surface of hepatocytes to promote LDLR degradation within the liver. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C174849 |
|
| CAS_Registry |
1245916-14-6
|
|
| code |
C174849
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA
|
|
| DEFINITION |
A human immunoglobulin G1 (IgG1) monoclonal antibody directed against human proprotein convertase subtilisin/kexin type 9 (PCSK9), that can be used in the treatment of hypercholesterolemia. Upon administration, alirocumab targets, binds to and inhibits the activity of PCSK9. This prevents the binding of PCSK9 to low-density lipoprotein receptor (LDLR) on hepatocytes and prevents its degradation. This increases LDLR on hepatocytes and increases the liver's ability to remove LDL cholesterol (LDL-C) from the blood, thereby lowering LDL-C levels. PCSK9 binds to LDLR on the surface of hepatocytes to promote LDLR degradation within the liver.
|
|
| Display_Name |
Alirocumab
|
|
| FDA_UNII_Code |
PP0SHH6V16
|
|
| FULL_SYN |
ALIROCUMAB Alirocumab Praluent
|
|
| label |
Alirocumab
|
|
| NCI_Drug_Dictionary_ID |
811355
|
|
| NCI_META_CUI |
CL1412123
|
|
| Preferred_Name |
Alirocumab
|
|
| prefixIRI |
Thesaurus:C174849
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|
| Semantic_Type |
Pharmacologic Substance
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|
| subClassOf |
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