loading...| Preferred Name |
Troponin I |
|
| Synonyms |
TNNI TnI Troponin I |
|
| Definitions |
Troponin I, troponin T, and troponin C are the three closely associated subunits of the troponin complex of thin filaments in muscle. The complex serves as a calcium-sensitive switch that regulates muscle contraction. In the absence of calcium, Troponin I binds actin, inhibits actomyosin ATPase activity, and inhibits F-actin-myosin interactions. The troponin I gene family comprises three isoforms: skeletal TNI-fast, skeletal TNI-slow, and TNI-cardiac. (from OMIM 191044, 191043, 191042 and NCI) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17343 |
|
| code |
C17343 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
|
| Contributing_Source |
CTRP |
|
| DEFINITION |
Troponin I, troponin T, and troponin C are the three closely associated subunits of the troponin complex of thin filaments in muscle. The complex serves as a calcium-sensitive switch that regulates muscle contraction. In the absence of calcium, Troponin I binds actin, inhibits actomyosin ATPase activity, and inhibits F-actin-myosin interactions. The troponin I gene family comprises three isoforms: skeletal TNI-fast, skeletal TNI-slow, and TNI-cardiac. (from OMIM 191044, 191043, 191042 and NCI) |
|
| Display_Name |
Troponin I |
|
| FULL_SYN |
TNNI TnI Troponin I |
|
| label |
Troponin I |
|
| Legacy Concept Name |
Troponin-I |
|
| Preferred_Name |
Troponin I |
|
| prefixIRI |
Thesaurus:C17343 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein |
|
| UMLS_CUI |
C0077401 |
|
| subClassOf |