National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Streptavidin

Synonyms

Streptavidin

streptavidin

Definitions

A bacterial protein that has high affinity for biotin. The non-covalent streptavidin-biotin complex is resistant to organic solvents, denaturants, detergents, proteolytic enzymes, and extremes in temperatures and pH. The stability of the complex is leveraged by many research and clinical procedures including protein purification, chemiluminescent, fluorescent and colorimetric immunostaining, atomic force microscopy, synthesis of carbon nanotubes and DNA-based nanoparticles, and targeted immunotherapy.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17334

ALT_DEFINITION

A small bacterial protein that binds with high affinity to the vitamin biotin. This streptavidin-biotin combination can be used to link molecules such as radioisotopes and monoclonal antibodies together. These bound products have the property of being attracted to, and attaching to, cancer cells, rather than normal cells. The radiolabeled products are more easily removed from the body, thus decreasing their toxicity.

code

C17334

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

DEFINITION

A bacterial protein that has high affinity for biotin. The non-covalent streptavidin-biotin complex is resistant to organic solvents, denaturants, detergents, proteolytic enzymes, and extremes in temperatures and pH. The stability of the complex is leveraged by many research and clinical procedures including protein purification, chemiluminescent, fluorescent and colorimetric immunostaining, atomic force microscopy, synthesis of carbon nanotubes and DNA-based nanoparticles, and targeted immunotherapy.

FULL_SYN

Streptavidin

streptavidin

label

Streptavidin

Legacy Concept Name

Streptavidin

NCI_Drug_Dictionary_ID

42952

PDQ_Closed_Trial_Search_ID

42952

PDQ_Open_Trial_Search_ID

42952

Preferred_Name

Streptavidin

prefixIRI

Thesaurus:C17334

Semantic_Type

Biologically Active Substance

UMLS_CUI

C0075278

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16319

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