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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Heparan Sulfate Proteoglycan | |
| Synonyms |
Heparan Sulfate Proteoglycan HSPG |
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| Definitions |
Heparan Sulfate Proteoglycan is an extracellular matrix and vascular basal lamina component. Heparan Sulfate is also an essential co-factor in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions. Degradation by heparanase is a key step in extravasation by tumor cells and migrating leukocytes, as well as in angiogenesis, wound healing, and smooth muscle proliferation. In basement membranes, heparan sulfate may stabilize other molecules and influence glomerular permeability and cell adhesion. (From OMIM 142461 and NCI) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17300 |
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| CHEBI_ID |
CHEBI:35721 CHEBI:24499
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| code |
C17300
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| DEFINITION |
Heparan Sulfate Proteoglycan is an extracellular matrix and vascular basal lamina component. Heparan Sulfate is also an essential co-factor in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions. Degradation by heparanase is a key step in extravasation by tumor cells and migrating leukocytes, as well as in angiogenesis, wound healing, and smooth muscle proliferation. In basement membranes, heparan sulfate may stabilize other molecules and influence glomerular permeability and cell adhesion. (From OMIM 142461 and NCI)
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| FULL_SYN |
Heparan Sulfate Proteoglycan HSPG
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| label |
Heparan Sulfate Proteoglycan
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| Legacy Concept Name |
Heparan_Sulfate_Proteoglycan
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|
| Preferred_Name |
Heparan Sulfate Proteoglycan
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| prefixIRI |
Thesaurus:C17300
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| Semantic_Type |
Amino Acid, Peptide, or Protein Biologically Active Substance
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| UMLS_CUI |
C0062503
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| subClassOf |
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