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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Caspofungin Acetate | |
| Synonyms |
caspofungin acetate Caspofungin Acetate CASPOFUNGIN ACETATE Cancidas |
|
| Definitions |
The acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the fungus Glarea lozoyensis. Caspofungin inhibits 1,3-beta-glucan synthase, resulting in decreased synthesis of beta(1,3)-D-glucan (an essential component of the fungal cell wall), weakening of the fungal cell wall, and fungal cell wall rupture. This agent is active against Aspergillus and Candida species. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1724 |
|
| ALT_DEFINITION |
A drug used to prevent or treat infections caused by a fungus (a type of microorganism). It belongs to the family of drugs called antifungal agents.
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|
| CAS_Registry |
179463-17-3
|
|
| CHEBI_ID |
CHEBI:59900
|
|
| Chemical_Formula |
C52H88N10O15.2C2H4O2
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|
| code |
C1724
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA
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|
| DEFINITION |
The acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the fungus Glarea lozoyensis. Caspofungin inhibits 1,3-beta-glucan synthase, resulting in decreased synthesis of beta(1,3)-D-glucan (an essential component of the fungal cell wall), weakening of the fungal cell wall, and fungal cell wall rupture. This agent is active against Aspergillus and Candida species.
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|
| Display_Name |
Caspofungin Acetate
|
|
| FDA_UNII_Code |
VUW370O5QE
|
|
| FULL_SYN |
caspofungin acetate Caspofungin Acetate CASPOFUNGIN ACETATE Cancidas
|
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Caspofungin Acetate
|
|
| Legacy Concept Name |
Caspofungin_Acetate
|
|
| NCI_Drug_Dictionary_ID |
38182
|
|
| PDQ_Closed_Trial_Search_ID |
38182
|
|
| PDQ_Open_Trial_Search_ID |
38182
|
|
| Preferred_Name |
Caspofungin Acetate
|
|
| prefixIRI |
Thesaurus:C1724
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
|
|
| UMLS_CUI |
C0935942
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| subClassOf |
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