loading...| Preferred Name |
Multisystem Inflammatory Syndrome in Children |
|
| Synonyms |
Multisystem Inflammatory Syndrome in Children (MIS-C) Pediatric Multi-System Inflammatory Syndrome Potentially Associated with COVID-19 Multisystem inflammatory syndrome in children (MIS-C) Multisystem Inflammatory Syndrome in Children Multisystem Inflammatory Syndrome in Children Associated with COVID-19 Pediatric Multisystem Inflammatory Syndrome Pediatric Inflammatory Multisystem Syndrome COVID-19-Related Pediatric Inflammatory Multisystem Syndrome MIS-C MISC PIMS PMIS |
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| Definitions |
A rare syndrome temporally associated with COVID-19 in children, marked by persistent fever, inflammation (neutrophilia, elevated C-reactive protein (CRP), and lymphopenia), poor function in one or more organs, and other specific clinical and laboratory features not attributable to other infections. The characteristics of this syndrome appear to be similar to toxic shock syndrome and Kawasaki disease. The following variable signs and symptoms have been most commonly reported to date: coagulopathy, cardiac dysfunction, diarrhea, abdominal distension, other GI symptoms (with some children having positive stool tests for SARS-CoV-2), and acute kidney injury. Respiratory symptoms are not always a prominent feature in these cases. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C172127 |
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| ALT_DEFINITION |
The occurrence of fever, laboratory evidence of inflammation, and evidence of clinically severe illness requiring hospitalization with multisystem (greater than or equal to 2) organ involvement AND No plausible alternative diagnoses AND Positive for current or recent SARS-CoV-2 infection by RT-PCR, serology, or antigen test OR exposure to a suspected or confirmed COVID-19 case within 4 wk prior to symptom onset in an individual aged less than 21 y |
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| code |
C172127 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191670 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191200 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177415 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179027 |
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| Contributing_Source |
ACC/AHA SeroNet |
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| DEFINITION |
A rare syndrome temporally associated with COVID-19 in children, marked by persistent fever, inflammation (neutrophilia, elevated C-reactive protein (CRP), and lymphopenia), poor function in one or more organs, and other specific clinical and laboratory features not attributable to other infections. The characteristics of this syndrome appear to be similar to toxic shock syndrome and Kawasaki disease. The following variable signs and symptoms have been most commonly reported to date: coagulopathy, cardiac dysfunction, diarrhea, abdominal distension, other GI symptoms (with some children having positive stool tests for SARS-CoV-2), and acute kidney injury. Respiratory symptoms are not always a prominent feature in these cases. |
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| FULL_SYN |
Multisystem Inflammatory Syndrome in Children (MIS-C) Pediatric Multi-System Inflammatory Syndrome Potentially Associated with COVID-19 Multisystem inflammatory syndrome in children (MIS-C) Multisystem Inflammatory Syndrome in Children Multisystem Inflammatory Syndrome in Children Associated with COVID-19 Pediatric Multisystem Inflammatory Syndrome Pediatric Inflammatory Multisystem Syndrome COVID-19-Related Pediatric Inflammatory Multisystem Syndrome MIS-C MISC PIMS PMIS |
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| Has_ACC-AHA_SARS2_Authorized_Value |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17998 |
|
| label |
Multisystem Inflammatory Syndrome in Children |
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| NCI_META_CUI |
CL1406225 |
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| Preferred_Name |
Multisystem Inflammatory Syndrome in Children |
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| prefixIRI |
Thesaurus:C172127 |
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| Semantic_Type |
Disease or Syndrome |
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| subClassOf |