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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Voriconazole | |
| Synonyms |
(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol VORICONAZOLE voriconazole Voriconazole Vfend |
|
| Definitions |
A synthetic triazole with antifungal activity. Voriconazole selectively inhibits 14-alpha-lanosterol demethylation in fungi, preventing the production of ergosterol, an essential constituent of the fungal cell membrane, and resulting in fungal cell lysis. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1707 |
|
| Accepted_Therapeutic_Use_For |
Aspergillosis, invasive; Esophageal candidiasis; Fungal infections, non-aspergillosis
|
|
| ALT_DEFINITION |
A drug that treats infections caused by fungi.
|
|
| CAS_Registry |
137234-62-9
|
|
| CHEBI_ID |
CHEBI:10023
|
|
| Chemical_Formula |
C16H14F3N5O
|
|
| code |
C1707
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
CTRP FDA HemOnc
|
|
| DEFINITION |
A synthetic triazole with antifungal activity. Voriconazole selectively inhibits 14-alpha-lanosterol demethylation in fungi, preventing the production of ergosterol, an essential constituent of the fungal cell membrane, and resulting in fungal cell lysis. (NCI04)
|
|
| Display_Name |
Voriconazole
|
|
| FDA_UNII_Code |
JFU09I87TR
|
|
| FULL_SYN |
(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol VORICONAZOLE voriconazole Voriconazole Vfend
|
|
| label |
Voriconazole
|
|
| Legacy Concept Name |
Voriconazole
|
|
| NCI_Drug_Dictionary_ID |
42690
|
|
| PDQ_Closed_Trial_Search_ID |
42690
|
|
| PDQ_Open_Trial_Search_ID |
42690
|
|
| Preferred_Name |
Voriconazole
|
|
| prefixIRI |
Thesaurus:C1707
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
|
|
| UMLS_CUI |
C0393080
|
|
| subClassOf |
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