loading...| Preferred Name |
Zoledronic Acid |
|
| Synonyms |
Zoledronate NDC-Zoledronate [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic Acid zoledronic acid Zoledronic acid Zoledronic Acid ZOLEDRONIC ACID Aclasta CGP 42446 CGP42446A Reclast ZOL 446 Zometa |
|
| Definitions |
A synthetic imidazole bisphosphonate analog of pyrophosphate with anti-bone-resorption activity. A third-generation bisphosphonate, zoledronic acid binds to hydroxyapatite crystals in the bone matrix, slowing their dissolution and inhibiting the formation and aggregation of these crystals. This agent also inhibits farnesyl pyrophosphate synthase, an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which are important in the process of osteoclast turnover. Decreased bone turnover and stabilization of the bone matrix contribute to the analgesic effect of zoledronic acid with respect to painful osteoblastic lesions. The agent also reduces serum calcium concentrations associated with hypercalcemia. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1699 |
|
| Accepted_Therapeutic_Use_For |
Hypercalcemia of malignancy; Multiple myeloma and metastatic bone lesions from solid tumors; Paget's disease |
|
| ALT_DEFINITION |
A drug used to treat patients with hypercalcemia (high blood levels of calcium) caused by cancer. It is also used together with other drugs to treat multiple myeloma and to prevent bone fractures and reduce bone pain in people who have cancer that has spread to the bone. It is a type of bisphosphonate. |
|
| CAS_Registry |
165800-06-6 |
|
| Chemical_Formula |
C5H10N2O7P2.H2O |
|
| code |
C1699 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179531 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc PCDC |
|
| DEFINITION |
A synthetic imidazole bisphosphonate analog of pyrophosphate with anti-bone-resorption activity. A third-generation bisphosphonate, zoledronic acid binds to hydroxyapatite crystals in the bone matrix, slowing their dissolution and inhibiting the formation and aggregation of these crystals. This agent also inhibits farnesyl pyrophosphate synthase, an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which are important in the process of osteoclast turnover. Decreased bone turnover and stabilization of the bone matrix contribute to the analgesic effect of zoledronic acid with respect to painful osteoblastic lesions. The agent also reduces serum calcium concentrations associated with hypercalcemia. |
|
| Display_Name |
Zoledronic Acid |
|
| FDA_UNII_Code |
6XC1PAD3KF |
|
| FULL_SYN |
Zoledronate NDC-Zoledronate [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic Acid zoledronic acid Zoledronic acid Zoledronic Acid ZOLEDRONIC ACID Aclasta CGP 42446 CGP42446A Reclast ZOL 446 Zometa |
|
| Has_Salt_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Zoledronic Acid |
|
| Legacy Concept Name |
Zoledronate |
|
| Maps_To |
Zoledronic Acid |
|
| NCI_Drug_Dictionary_ID |
42507 |
|
| NSC Number |
721517 |
|
| PDQ_Closed_Trial_Search_ID |
42507 |
|
| PDQ_Open_Trial_Search_ID |
42507 |
|
| Preferred_Name |
Zoledronic Acid |
|
| prefixIRI |
Thesaurus:C1699 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0257685 |
|
| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C443 |