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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Insulin-Like Growth Factor II | |
| Synonyms |
Insulin-Like Growth Factor II Somatomedin-A Insulin-Like Growth Factor 2 Somatomedin A IGF-2 IGF-II IGF2 |
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| Definitions |
Insulin-like growth factor II (180 aa, ~20 kDa) is encoded by the human IGF2 gene. This protein plays a role in cellular growth, development, and mitogenesis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16744 |
|
| code |
C16744
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
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| Contributing_Source |
CTRP
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|
| DEFINITION |
Insulin-like growth factor II (180 aa, ~20 kDa) is encoded by the human IGF2 gene. This protein plays a role in cellular growth, development, and mitogenesis.
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| DesignNote |
Similar to insulin, the full length insulin-like growth factor II precursor protein is cleaved at positions 24 or 25 and at positions 91 and 180 to release a 67 or 66 amino acid growth factor and an 89 amino acid E peptide. The E peptide can be further processed to release prepeptin. (UniProt)
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| Display_Name |
Insulin-Like Growth Factor II
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|
| FULL_SYN |
Insulin-Like Growth Factor II Somatomedin-A Insulin-Like Growth Factor 2 Somatomedin A IGF-2 IGF-II IGF2
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|
| label |
Insulin-Like Growth Factor II
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|
| Legacy Concept Name |
Insulin-Like_Growth_Factor-2
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|
| OMIM_Number |
147470
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|
| Preferred_Name |
Insulin-Like Growth Factor II
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|
| prefixIRI |
Thesaurus:C16744
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| Semantic_Type |
Amino Acid, Peptide, or Protein
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| Swiss_Prot |
P01344
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| UMLS_CUI |
C1569730
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| subClassOf |
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