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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Insulin-Like Growth Factor I | |
| Synonyms |
Insulin-Like Growth Factor I Somatomedin-C Mechano Growth Factor Insulin-Like Growth Factor 1 Insulin-Like Growth Factor-I Somatomedin C IGF I IGF-1 IGF-I IGF1 MGF |
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| Definitions |
Insulin-like growth factor I (195 aa, ~22 kDa) is encoded by the human IGF1 gene. This protein may be involved in the regulation of glucose metabolism. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16743 |
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| code |
C16743
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
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| Contributing_Source |
CTRP
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| DEFINITION |
Insulin-like growth factor I (195 aa, ~22 kDa) is encoded by the human IGF1 gene. This protein may be involved in the regulation of glucose metabolism.
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| DesignNote |
Elevated serum levels of insulin-like growth factor-1 (IGF-1) may identify premenopausal women who are likely to develop breast cancer before age 50. (Int J Cancer. 2000; 88: 828-832, via Medscape) Similar to insulin, the full length insulin-like growth factor I precursor protein is cleaved at positions 48 and 188 to release a 70 amino acid growth factor and a 77 amino acid E peptide. (UniProt)
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| Display_Name |
Insulin-Like Growth Factor I
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| FULL_SYN |
Insulin-Like Growth Factor I Somatomedin-C Mechano Growth Factor Insulin-Like Growth Factor 1 Insulin-Like Growth Factor-I Somatomedin C IGF I IGF-1 IGF-I IGF1 MGF
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|
| label |
Insulin-Like Growth Factor I
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| Legacy Concept Name |
Insulin-Like_Growth_Factor-1
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| OMIM_Number |
147440
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| Preferred_Name |
Insulin-Like Growth Factor I
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| prefixIRI |
Thesaurus:C16743
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| Semantic_Type |
Amino Acid, Peptide, or Protein
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| Swiss_Prot |
P05019
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| UMLS_CUI |
C3712803
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| subClassOf |
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