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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | DNA Damage | |
| Synonyms |
DNA Damage |
|
| Definitions |
Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16507 |
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| code |
C16507
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| Concept_In_Subset | ||
| Contributing_Source |
CTRP
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| DEFINITION |
Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis.
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| Display_Name |
DNA Damage
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| FULL_SYN |
DNA Damage
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|
| label |
DNA Damage
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|
| Legacy Concept Name |
DNA_Damage
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| Preferred_Name |
DNA Damage
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| prefixIRI |
Thesaurus:C16507
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| Semantic_Type |
Cell or Molecular Dysfunction
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| UMLS_CUI |
C0012860
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| subClassOf |
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