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National Cancer Institute Thesaurus
| Preferred Name | Trastuzumab | |
| Synonyms |
Herceptin Biosimilar PF-05280014 Trastuzumab-qyyp Trastuzumab-dttb Trastuzumab Biosimilar CT-P6 Trastuzumab Biosimilar PF-05280014 TRASTUZUMAB Trastuzumab Biosimilar QL1701 Trastuzumab Biosimilar SIBP-01 Trastuzumab Trastuzumab-pkrb Immunoglobulin G 1 (Human-Mouse Monoclonal RhuMab HER2gamma1-Chain Antihuman p185(Sup c-erbB2) Receptor), Disulfide with Human-Mouse Monoclonal RhuMab HER2 Light Chain, Dimer Herceptin Trastuzumab Biosimilar PF-05280014 rhuMAb HER2 Trastuzumab Biosimilar SB3 Trastuzumab-anns trastuzumab biosimilar EG12014 PF-05280014 Trastuzumab Biosimilar ABP 980 Trastuzumab Biosimilar HLX02 Trastuzumab Biosimilar ALT02 trastuzumab Trastuzumab-dkst ABP 980 ALT02 Biceltis CANMab CT-P06 CT-P6 Herceptin Herclon Hertraz Herzuma Kanjinti Ogivri Ontruzant QL 1701 QL-1701 QL1701 RO0452317 SB3 Trazimera |
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| Definitions |
A recombinant humanized monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2). After binding to HER2 on the tumor cell surface, trastuzumab induces an antibody-dependent cell-mediated cytotoxicity against tumor cells that overexpress HER2. HER2 is overexpressed by many adenocarcinomas, particularly breast adenocarcinomas. (NCI04) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1647 |
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| Accepted_Therapeutic_Use_For |
Breast cancer overexpressing HER2 protein; Pancreatic cancer overexpressing p185HER2
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| ALT_DEFINITION |
A drug used alone or with other drugs to treat certain types of breast cancer, stomach cancer, and gastroesophageal junction cancer that are HER2 positive. It is also being studied in the treatment of other types of cancer. Trastuzumab binds to a protein called HER2, which is found on some cancer cells. This may help the immune system kill cancer cells. Trastuzumab is a type of monoclonal antibody and a type of HER2 receptor antagonist.
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| CAS_Registry |
180288-69-1
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| code |
C1647
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC HemOnc
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| DEFINITION |
A recombinant humanized monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2). After binding to HER2 on the tumor cell surface, trastuzumab induces an antibody-dependent cell-mediated cytotoxicity against tumor cells that overexpress HER2. HER2 is overexpressed by many adenocarcinomas, particularly breast adenocarcinomas. (NCI04)
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| Display_Name |
Trastuzumab
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| FDA_UNII_Code |
P188ANX8CK
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| FULL_SYN |
Herceptin Biosimilar PF-05280014 Trastuzumab-qyyp Trastuzumab-dttb Trastuzumab Biosimilar CT-P6 Trastuzumab Biosimilar PF-05280014 TRASTUZUMAB Trastuzumab Biosimilar QL1701 Trastuzumab Biosimilar SIBP-01 Trastuzumab Trastuzumab-pkrb Immunoglobulin G 1 (Human-Mouse Monoclonal RhuMab HER2gamma1-Chain Antihuman p185(Sup c-erbB2) Receptor), Disulfide with Human-Mouse Monoclonal RhuMab HER2 Light Chain, Dimer Herceptin Trastuzumab Biosimilar PF-05280014 rhuMAb HER2 Trastuzumab Biosimilar SB3 Trastuzumab-anns trastuzumab biosimilar EG12014 PF-05280014 Trastuzumab Biosimilar ABP 980 Trastuzumab Biosimilar HLX02 Trastuzumab Biosimilar ALT02 trastuzumab Trastuzumab-dkst ABP 980 ALT02 Biceltis CANMab CT-P06 CT-P6 Herceptin Herclon Hertraz Herzuma Kanjinti Ogivri Ontruzant QL 1701 QL-1701 QL1701 RO0452317 SB3 Trazimera
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| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Trastuzumab
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| Legacy Concept Name |
Trastuzumab
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| Maps_To |
Trastuzumab Anti-HER2 Monoclonal Antibody CT-P6
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| NCI_Drug_Dictionary_ID |
42265
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| NSC Number |
688097
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| PDQ_Closed_Trial_Search_ID |
42265
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| PDQ_Open_Trial_Search_ID |
42265
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| Preferred_Name |
Trastuzumab
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| prefixIRI |
Thesaurus:C1647
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance Immunologic Factor
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| UMLS_CUI |
C0728747
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| subClassOf |
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