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National Cancer Institute Thesaurus
| Preferred Name | Levofloxacin | |
| Synonyms |
7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic Acid, 9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, Hydrate (2:1), (S)- LEVOFLOXACIN levofloxacin Levofloxacin (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic Acid Hydrate (2:1) Levofloxacin Hydrate Levaquin Quixin |
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| Definitions |
A broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1586 |
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| ALT_DEFINITION |
A substance used to treat bacterial infections. It belongs to the family of drugs called quinolone antibiotics.
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| CAS_Registry |
138199-71-0
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| Chemical_Formula |
2C18H20FN3O4.H2O
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| code |
C1586
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
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| Contributing_Source |
CTRP FDA HemOnc
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| DEFINITION |
A broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth.
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| Display_Name |
Levofloxacin
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| FDA_UNII_Code |
6GNT3Y5LMF
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| FULL_SYN |
7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic Acid, 9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, Hydrate (2:1), (S)- LEVOFLOXACIN levofloxacin Levofloxacin (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic Acid Hydrate (2:1) Levofloxacin Hydrate Levaquin Quixin
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|
| label |
Levofloxacin
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| Legacy Concept Name |
Levofloxacin
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| NCI_Drug_Dictionary_ID |
37941
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| PDQ_Closed_Trial_Search_ID |
37941
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| PDQ_Open_Trial_Search_ID |
37941
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| Preferred_Name |
Levofloxacin
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| prefixIRI |
Thesaurus:C1586
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| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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| UMLS_CUI |
C0282386
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| subClassOf |
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