loading...| Preferred Name | Alitretinoin | |
| Synonyms |
9-cis Retinoic Acid 9-cis-Retinoic Acid 9-cis retinoic acid 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-trans-4-trans-6-cis-8-trans-nonatetraenoic Acid 9-Cis-Retinoic Acid ALITRETINOIN Retinoicacid-9-cis Alitretinoin 9-cRA 9-cis-RA ALRT1057 LGD1057 Panretin Panretyn Panrexin |
|
| Definitions |
An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities. Alitretinoin binds to and activates nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR); these activated receptors act as transcription factors, regulating gene expression that results in the inhibition of cell proliferation, induction of cell differentiation, and apoptosis of both normal cells and tumor cells. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1574 |
|
| Accepted_Therapeutic_Use_For |
Topical treatment of cutaneous lesions in patients with AIDS-related Kaposi sarcoma |
|
| ALT_DEFINITION |
A drug being studied for cancer prevention. It belongs to the family of drugs called retinoids. |
|
| CAS_Registry |
5300-03-8 |
|
| CHEBI_ID |
CHEBI:50648 |
|
| Chemical_Formula |
C20H28O2 |
|
| code |
C1574 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC HemOnc |
|
| DEFINITION |
An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities. Alitretinoin binds to and activates nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR); these activated receptors act as transcription factors, regulating gene expression that results in the inhibition of cell proliferation, induction of cell differentiation, and apoptosis of both normal cells and tumor cells. |
|
| FDA_UNII_Code |
1UA8E65KDZ |
|
| FULL_SYN |
9-cis Retinoic Acid 9-cis-Retinoic Acid 9-cis retinoic acid 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-trans-4-trans-6-cis-8-trans-nonatetraenoic Acid 9-Cis-Retinoic Acid ALITRETINOIN Retinoicacid-9-cis Alitretinoin 9-cRA 9-cis-RA ALRT1057 LGD1057 Panretin Panretyn Panrexin |
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| Is_Value_For_GDC_Property | ||
| label |
Alitretinoin |
|
| Legacy Concept Name |
Alitretinoin |
|
| Maps_To |
Alitretinoin |
|
| NCI_Drug_Dictionary_ID |
42147 |
|
| NSC Number |
659772 |
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| PDQ_Closed_Trial_Search_ID |
42147 |
|
| PDQ_Open_Trial_Search_ID |
42147 |
|
| Preferred_Name |
Alitretinoin |
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| prefixIRI |
Thesaurus:C1574 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0281666 |
|
| subClassOf |