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National Cancer Institute Thesaurus
| Preferred Name | Letrozole | |
| Synonyms |
4,4'-(1H-1,2,4triazol-1-ylmethylene)dibenzonitrile CGS 20267 Femara Fempro LETROZOLE Letrozole letrozole |
|
| Definitions |
A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1527 |
|
| Accepted_Therapeutic_Use_For |
Hormone receptor-positive early breast cancer; Delayed puberty; Endometrial cancer; Ovulatory induction
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|
| ALT_DEFINITION |
A drug used to treat advanced breast cancer in postmenopausal women. Letrozole causes a decrease in the amount of estrogen made by the body. It is a type of aromatase inhibitor.
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|
| CAS_Registry |
112809-51-5
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|
| CHEBI_ID |
CHEBI:6413
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|
| Chemical_Formula |
C17H11N5
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|
| code |
C1527
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc
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|
| DEFINITION |
A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis.
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|
| Display_Name |
Letrozole
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|
| FDA_UNII_Code |
7LKK855W8I
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|
| FULL_SYN |
4,4'-(1H-1,2,4triazol-1-ylmethylene)dibenzonitrile CGS 20267 Femara Fempro LETROZOLE Letrozole letrozole
|
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Letrozole
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|
| Legacy Concept Name |
Letrozole
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|
| Maps_To |
Letrozole
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|
| NCI_Drug_Dictionary_ID |
42086
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|
| NSC Number |
719345
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|
| PDQ_Closed_Trial_Search_ID |
42086
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|
| PDQ_Open_Trial_Search_ID |
42086
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|
| Preferred_Name |
Letrozole
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|
| prefixIRI |
Thesaurus:C1527
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0246421
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| subClassOf |
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