loading...| Preferred Name |
Phenyl Acetate |
|
| Synonyms |
Acetic Acid Phenyl Ester PHENYL ACETATE Phenyl acetate Phenyl Acetate Acetylphenol phenylacetate |
|
| Definitions |
An aromatic fatty acid metabolite of phenylalanine with potential antineoplastic activity. Naturally occurring in mammals, phenylacetate induces differentiation, growth inhibition, and apoptosis in tumor cells. Implicated mechanisms of action include decreased protein prenylation, activation of the peroxisome proliferation-activated receptors, inhibition of DNA methylation, and depletion of glutamine. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1501 |
|
| Accepted_Therapeutic_Use_For |
Adjunctive therapy for the prevention and treatment of hyperammonemia in the chronic management of patients with urea cycle enzymopathy |
|
| ALT_DEFINITION |
A drug being studied in the treatment of cancer. |
|
| CAS_Registry |
122-79-2 |
|
| CHEBI_ID |
CHEBI:8082 |
|
| Chemical_Formula |
C8H8O2 |
|
| code |
C1501 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC |
|
| DEFINITION |
An aromatic fatty acid metabolite of phenylalanine with potential antineoplastic activity. Naturally occurring in mammals, phenylacetate induces differentiation, growth inhibition, and apoptosis in tumor cells. Implicated mechanisms of action include decreased protein prenylation, activation of the peroxisome proliferation-activated receptors, inhibition of DNA methylation, and depletion of glutamine. (NCI04) |
|
| FDA_UNII_Code |
355G9R500Y |
|
| FULL_SYN |
Acetic Acid Phenyl Ester PHENYL ACETATE Phenyl acetate Phenyl Acetate Acetylphenol phenylacetate |
|
| Is_Value_For_GDC_Property | ||
| label |
Phenyl Acetate |
|
| Legacy Concept Name |
Phenyl_Acetate |
|
| Maps_To |
Phenyl Acetate |
|
| NCI_Drug_Dictionary_ID |
41664 |
|
| NSC Number |
27795 |
|
| PDQ_Closed_Trial_Search_ID |
41664 |
|
| PDQ_Open_Trial_Search_ID |
41664 |
|
| Preferred_Name |
Phenyl Acetate |
|
| prefixIRI |
Thesaurus:C1501 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0220893 |
|
| subClassOf |