loading...| Preferred Name | Bedaquiline Fumarate | |
| Synonyms |
BDQ Fumarate Bedaquiline Fumarate BEDAQUILINE FUMARATE R403323 Sirturo |
|
| Definitions |
The fumarate salt form of bedaquiline, an orally bioavailable diarylquinoline antimycobacterial agent, that can be used in the treatment of pulmonary multi-drug resistant tuberculosis (MDR-TB). Upon oral administration, bedaquiline specifically binds to subunit c of Mycobacterium tuberculosis (M. tuberculosis) adenosine 5'-triphosphate (ATP) synthase, thereby preventing ATP synthase activity. This inhibits ATP synthesis in M. tuberculosis, thereby blocking its energy metabolism and killing M. tuberculosis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142949 |
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| CAS_Registry |
845533-86-0 |
|
| code |
C142949 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The fumarate salt form of bedaquiline, an orally bioavailable diarylquinoline antimycobacterial agent, that can be used in the treatment of pulmonary multi-drug resistant tuberculosis (MDR-TB). Upon oral administration, bedaquiline specifically binds to subunit c of Mycobacterium tuberculosis (M. tuberculosis) adenosine 5'-triphosphate (ATP) synthase, thereby preventing ATP synthase activity. This inhibits ATP synthesis in M. tuberculosis, thereby blocking its energy metabolism and killing M. tuberculosis. |
|
| FDA_UNII_Code |
P04QX2C1A5 |
|
| FULL_SYN |
BDQ Fumarate Bedaquiline Fumarate BEDAQUILINE FUMARATE R403323 Sirturo |
|
| label |
Bedaquiline Fumarate |
|
| Preferred_Name |
Bedaquiline Fumarate |
|
| prefixIRI |
Thesaurus:C142949 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C3530515 |
|
| subClassOf |