National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Epipodophyllotoxin Compound
Synonyms

epipodophyllotoxin

Epipodophyllotoxin Compound
Definitions

An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1331
ALT_DEFINITION

A substance being studied in the treatment of some types of cancer. Epipodophyllotoxin is extracted from the mandrake root Podophyllum peltatum. It is a type of topoisomerase inhibitor.
code

C1331
DEFINITION

An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death.
FULL_SYN

epipodophyllotoxin

Epipodophyllotoxin Compound
label

Epipodophyllotoxin Compound
Legacy Concept Name

Epipodophyllotoxin_Compound
Preferred_Name

Epipodophyllotoxin Compound
prefixIRI

Thesaurus:C1331
Semantic_Type

Organic Chemical

Pharmacologic Substance
UMLS_CUI

C0086243
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1931

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1968
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