loading...| Preferred Name |
Epipodophyllotoxin Compound |
|
| Synonyms |
epipodophyllotoxin Epipodophyllotoxin Compound |
|
| Definitions |
An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1331 |
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| ALT_DEFINITION |
A substance being studied in the treatment of some types of cancer. Epipodophyllotoxin is extracted from the mandrake root Podophyllum peltatum. It is a type of topoisomerase inhibitor. |
|
| code |
C1331 |
|
| DEFINITION |
An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. |
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| FULL_SYN |
epipodophyllotoxin Epipodophyllotoxin Compound |
|
| label |
Epipodophyllotoxin Compound |
|
| Legacy Concept Name |
Epipodophyllotoxin_Compound |
|
| Preferred_Name |
Epipodophyllotoxin Compound |
|
| prefixIRI |
Thesaurus:C1331 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0086243 |
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| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1331 | ROO | SAME_URI | |
| http://purl.obolibrary.org/obo/NCIT_C1331 | BERO | LOOM | |
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1331 | ROO | LOOM |