Preferred Name |
Lithium Carbonate |
|
Synonyms |
LITHIUM CARBONATE Lithium Carbonate Lithium carbonate Escalith Eskalith Lithane Lithium Lithobid Lithonate Lithotabs |
|
Definitions |
The carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stem cells. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1318 |
|
CAS_Registry |
554-13-2 |
|
CHEBI_ID |
CHEBI:6504 |
|
Chemical_Formula |
CO3.2Li |
|
code |
C1318 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
Contributing_Source |
CTRP FDA |
|
DEFINITION |
The carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stem cells. |
|
Display_Name |
Lithium Carbonate |
|
FDA_UNII_Code |
2BMD2GNA4V |
|
FULL_SYN |
LITHIUM CARBONATE Lithium Carbonate Lithium carbonate Escalith Eskalith Lithane Lithium Lithobid Lithonate Lithotabs |
|
label |
Lithium Carbonate |
|
Legacy Concept Name |
Lithium_Carbonate |
|
NCI_Drug_Dictionary_ID |
39491 |
|
NSC Number |
16895 |
|
PDQ_Closed_Trial_Search_ID |
39491 |
|
PDQ_Open_Trial_Search_ID |
39491 |
|
Preferred_Name |
Lithium Carbonate |
|
prefixIRI |
Thesaurus:C1318 |
|
Semantic_Type |
Pharmacologic Substance Inorganic Chemical |
|
UMLS_CUI |
C0085217 |
|
subClassOf |