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National Cancer Institute Thesaurus
| Preferred Name | Vinorelbine | |
| Synonyms |
VINORELBINE 3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine vinorelbine Dihydroxydeoxynorvinkaleukoblastine 5'-Nor-Anhydrovinblastine nor-5'-Anhydrovinblastine Vinorelbine |
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| Definitions |
A semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. This agent may also interfere with amino acid, cyclic AMP. and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1275 |
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| Accepted_Therapeutic_Use_For |
Breast cancer; Cervical cancer; Non-small cell lung cancer; Ovarian cancer; Prostate cancer
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| ALT_DEFINITION |
An anticancer drug that belongs to the family of plant drugs called vinca alkaloids.
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|
| CAS_Registry |
71486-22-1
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|
| CHEBI_ID |
CHEBI:480999
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|
| Chemical_Formula |
C45H54N4O8
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|
| code |
C1275
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 |
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| Contributing_Source |
CTRP FDA GDC HemOnc PCDC
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|
| DEFINITION |
A semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. This agent may also interfere with amino acid, cyclic AMP. and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.
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|
| Display_Name |
Vinorelbine
|
|
| FDA_UNII_Code |
Q6C979R91Y
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|
| FULL_SYN |
VINORELBINE 3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine vinorelbine Dihydroxydeoxynorvinkaleukoblastine 5'-Nor-Anhydrovinblastine nor-5'-Anhydrovinblastine Vinorelbine
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|
| Has_Salt_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Vinorelbine
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|
| Legacy Concept Name |
Vinorelbine
|
|
| Maps_To |
Vinorelbine
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|
| Preferred_Name |
Vinorelbine
|
|
| prefixIRI |
Thesaurus:C1275
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0078257
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| subClassOf |
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