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National Cancer Institute Thesaurus
| Preferred Name | Vortioxetine Hydrobromide | |
| Synonyms |
VORTIOXETINE HYDROBROMIDE 1-(2-((2,4-Dimethylphenyl)sulfanyl)phenyl)piperazine Monohydrobromide Piperazine, 1-(2-((2,4-dimethylphenyl)thio)phenyl)-, Hydrobromide (1:1) Vortioxetine Hydrobromide Brintellix Trintellix |
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| Definitions |
A hydrobromide salt form of vortioxetine, a serotonin (5-HT) modulator and stimulator (SMS), with antidepressant activity. Vortioxetine inhibits the reuptake of serotonin and norepinephrine from the synaptic cleft and acts variably as a serotonin receptor agonist (5-HT1A), partial agonist (5-HT1B) or antagonist (5-HT3, 5-HT1D and 5-HT7). It is not clear how this agent's purported multimodal mechanism of action contributes to its antidepressant effect; however, it is presumed to increase the synaptic availability of serotonin and norepinephrine. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125653 |
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| CAS_Registry |
960203-27-4
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| code |
C125653
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
A hydrobromide salt form of vortioxetine, a serotonin (5-HT) modulator and stimulator (SMS), with antidepressant activity. Vortioxetine inhibits the reuptake of serotonin and norepinephrine from the synaptic cleft and acts variably as a serotonin receptor agonist (5-HT1A), partial agonist (5-HT1B) or antagonist (5-HT3, 5-HT1D and 5-HT7). It is not clear how this agent's purported multimodal mechanism of action contributes to its antidepressant effect; however, it is presumed to increase the synaptic availability of serotonin and norepinephrine.
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| FDA_UNII_Code |
TKS641KOAY
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| FULL_SYN |
VORTIOXETINE HYDROBROMIDE 1-(2-((2,4-Dimethylphenyl)sulfanyl)phenyl)piperazine Monohydrobromide Piperazine, 1-(2-((2,4-dimethylphenyl)thio)phenyl)-, Hydrobromide (1:1) Vortioxetine Hydrobromide Brintellix Trintellix
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| label |
Vortioxetine Hydrobromide
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| NCI_Drug_Dictionary_ID |
778329
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| PDQ_Closed_Trial_Search_ID |
778329
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| PDQ_Open_Trial_Search_ID |
778329
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| Preferred_Name |
Vortioxetine Hydrobromide
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| prefixIRI |
Thesaurus:C125653
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C3667599
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| subClassOf |
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