loading...| Preferred Name |
Pyrazofurin |
|
| Synonyms |
Pyrazomycin .beta.-Pyrazomycin Pyrazole, -3-carboxamide, 4-hydroxy-5-.beta.-L-ribofuranosyl- 4-Hydroxy-3-.beta.-D-ribofuranosylpyrazole-5-carboxamide PYRAZOFURIN Compound 47599 Pyrazofurin Pyrazole, -3-Carboxamide, 4-Hydroxy-5-beta-L-ribofuranosyl Pirazofurin 1H-Pyrazole-5-carboxamide, 4-Hydroxy-3-beta-D-ribofuranosyl- (9CI) 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-.beta.-D-ribofuranosyl- (9CI) Beta-Pyrazomycin 4-Hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamide 47599 PRZF |
|
| Definitions |
A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1208 |
|
| CAS_Registry |
30868-30-5 |
|
| Chemical_Formula |
C9H13N3O6 |
|
| code |
C1208 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. (NCI04) |
|
| FDA_UNII_Code |
4B15044GQZ |
|
| FULL_SYN |
Pyrazomycin .beta.-Pyrazomycin Pyrazole, -3-carboxamide, 4-hydroxy-5-.beta.-L-ribofuranosyl- 4-Hydroxy-3-.beta.-D-ribofuranosylpyrazole-5-carboxamide PYRAZOFURIN Compound 47599 Pyrazofurin Pyrazole, -3-Carboxamide, 4-Hydroxy-5-beta-L-ribofuranosyl Pirazofurin 1H-Pyrazole-5-carboxamide, 4-Hydroxy-3-beta-D-ribofuranosyl- (9CI) 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-.beta.-D-ribofuranosyl- (9CI) Beta-Pyrazomycin 4-Hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamide 47599 PRZF |
|
| label |
Pyrazofurin |
|
| Legacy Concept Name |
Pyrazofurin |
|
| NCI_Drug_Dictionary_ID |
39575 |
|
| NSC Number |
143095 |
|
| PDQ_Closed_Trial_Search_ID |
39575 |
|
| PDQ_Open_Trial_Search_ID |
39575 |
|
| Preferred_Name |
Pyrazofurin |
|
| prefixIRI |
Thesaurus:C1208 |
|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide Antibiotic |
|
| UMLS_CUI |
C0072661 |
|
| subClassOf |