National Cancer Institute Thesaurus

Last uploaded: February 23, 2024

Preferred Name	Orotidylate Decarboxylase Inhibitor
Synonyms	Orotidylate Decarboxylase Inhibitors Orotidine 5'-phosphate Decarboxylase Inhibitor Orotidylate Decarboxylase Inhibitor Orotidylic Acid Decarboxylase Inhibitor
Definitions	Any substance that inhibits orotidine 5'-phosphate decarboxylase (orotidylate decarboxylase), an enzyme that catalyzes the decarboxylation of orotidine monophosphate to form uridine monophosphate and is required for the de novo synthesis of uridine and pyrimidines. Inhibition of orotidine 5'-phosphate decarboxylase inhibits DNA, RNA, and protein synthesis.
ID	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2170
code	C2170
DEFINITION	Any substance that inhibits orotidine 5'-phosphate decarboxylase (orotidylate decarboxylase), an enzyme that catalyzes the decarboxylation of orotidine monophosphate to form uridine monophosphate and is required for the de novo synthesis of uridine and pyrimidines. Inhibition of orotidine 5'-phosphate decarboxylase inhibits DNA, RNA, and protein synthesis.
FULL_SYN	Orotidylate Decarboxylase Inhibitors Orotidine 5'-phosphate Decarboxylase Inhibitor Orotidylate Decarboxylase Inhibitor Orotidylic Acid Decarboxylase Inhibitor
label	Orotidylate Decarboxylase Inhibitor
Legacy Concept Name	Orotidylate_Decarboxylase_Inhibitor
Preferred_Name	Orotidylate Decarboxylase Inhibitor
prefixIRI	Thesaurus:C2170
Semantic_Type	Chemical Viewed Functionally
UMLS_CUI	C1518619
subClassOf	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C471

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Delete	Mapping To	Ontology	Source
	http://purl.obolibrary.org/obo/NCIT_C2170	BERO	LOOM