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National Cancer Institute Thesaurus
| Preferred Name | Nilutamide | |
| Synonyms |
1-(3'-Trifluoromethyl-4'-nitrophenyl)-4,4-dimethylimidazoline-3,5-dione 5,5-Dimethyl-3-[4-nitro-3-(trifluoro-methyl)phenyl]-2,4-imidazolidinedione Anandron NILUTAMIDE Nilandron Nilutamide RU-23908 nilutamide |
|
| Definitions |
A synthetic, nonsteroidal agent with antiandrogenic properties. Nilutamide preferentially binds to androgen receptors and blocks androgen receptor activation by testosterone and other androgens; this agent may inhibit androgen-dependent growth of normal and neoplastic prostate cells. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1173 |
|
| Accepted_Therapeutic_Use_For |
Prostate cancer
|
|
| ALT_DEFINITION |
A drug that blocks the effects of male hormones in the body. It is a type of antiandrogen.
|
|
| CAS_Registry |
63612-50-0
|
|
| CHEBI_ID |
CHEBI:7573
|
|
| Chemical_Formula |
C12H10F3N3O4
|
|
| code |
C1173
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192234 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc OORO
|
|
| DEFINITION |
A synthetic, nonsteroidal agent with antiandrogenic properties. Nilutamide preferentially binds to androgen receptors and blocks androgen receptor activation by testosterone and other androgens; this agent may inhibit androgen-dependent growth of normal and neoplastic prostate cells. (NCI04)
|
|
| Display_Name |
Nilutamide
|
|
| FDA_UNII_Code |
51G6I8B902
|
|
| FULL_SYN |
1-(3'-Trifluoromethyl-4'-nitrophenyl)-4,4-dimethylimidazoline-3,5-dione 5,5-Dimethyl-3-[4-nitro-3-(trifluoro-methyl)phenyl]-2,4-imidazolidinedione Anandron NILUTAMIDE Nilandron Nilutamide RU-23908 nilutamide
|
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Nilutamide
|
|
| Legacy Concept Name |
Nilutamide
|
|
| Maps_To |
Nilutamide
|
|
| NCI_Drug_Dictionary_ID |
40450
|
|
| NSC Number |
684588
|
|
| PDQ_Closed_Trial_Search_ID |
40450
|
|
| PDQ_Open_Trial_Search_ID |
40450
|
|
| Preferred_Name |
Nilutamide
|
|
| prefixIRI |
Thesaurus:C1173
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0722107
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|
| subClassOf |
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