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National Cancer Institute Thesaurus
| Preferred Name | Boceprevir | |
| Synonyms |
3-Azabicyclo(3.1.0)hexane-2-carboxamide, N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-((2S)-2-((((1,1- dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6- dimethyl-, (1R,2S,5S)- BOCEPREVIR Boceprevir EBP 520 SCH 503034 Victrelis |
|
| Definitions |
An orally bioavailable, synthetic tripeptide inhibitor of the nonstructural protein 3 and 4A complex (NS3/NS4A), with potential activity against hepatitis C virus (HCV) genotype 1. Upon administration, boceprevir reversibly binds to the active center of the HCV NS3/NS4A and prevents NS3/NS4A protease-mediated polyprotein maturation. This disrupts the processing of viral proteins and the formation of a viral replication complex, which inhibits viral replication in HCV genotrype 1-infected host cells. NS3, a serine protease, is essential for the proteolytic cleavages within the HCV polyprotein and plays a key role during HCV viral RNA replication. NS4A is an activating factor for NS3. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C117292 |
|
| CAS_Registry |
394730-60-0
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|
| code |
C117292
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA
|
|
| DEFINITION |
An orally bioavailable, synthetic tripeptide inhibitor of the nonstructural protein 3 and 4A complex (NS3/NS4A), with potential activity against hepatitis C virus (HCV) genotype 1. Upon administration, boceprevir reversibly binds to the active center of the HCV NS3/NS4A and prevents NS3/NS4A protease-mediated polyprotein maturation. This disrupts the processing of viral proteins and the formation of a viral replication complex, which inhibits viral replication in HCV genotrype 1-infected host cells. NS3, a serine protease, is essential for the proteolytic cleavages within the HCV polyprotein and plays a key role during HCV viral RNA replication. NS4A is an activating factor for NS3. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family.
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|
| Display_Name |
Boceprevir
|
|
| FDA_UNII_Code |
89BT58KELH
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|
| FULL_SYN |
3-Azabicyclo(3.1.0)hexane-2-carboxamide, N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-((2S)-2-((((1,1- dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6- dimethyl-, (1R,2S,5S)- BOCEPREVIR Boceprevir EBP 520 SCH 503034 Victrelis
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|
| Has_Target | ||
| label |
Boceprevir
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|
| NCI_Drug_Dictionary_ID |
763662
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|
| PDQ_Closed_Trial_Search_ID |
763662
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|
| PDQ_Open_Trial_Search_ID |
763662
|
|
| Preferred_Name |
Boceprevir
|
|
| prefixIRI |
Thesaurus:C117292
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C1738934
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| subClassOf |
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