loading...| Preferred Name |
Miltefosine |
|
| Synonyms |
n-Hexadecylphosphorylcholine 2-[[(Hexadecycloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium Inner Salt Hexadecylphosphocholine MILTEFOSINE Miltefosine Miltefosina Hexadecyl 2-(N,N,N-trimethylamino)ethyl Phosphate Choline Phosphate Hexadecyl Ester, Hydroxide, Inner Salt Miltefosinum D-18506 Miltefosin Miltex |
|
| Definitions |
An orally- and topically-active alkyl-phosphocholine compound with potential antineoplastic activity. Miltefosine targets cellular membranes, modulating cell membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. As an immunomodulator, miltefosine stimulates T-cells, macrophages and the expression of interleukin 3 (IL-3), granulocyte-macrophage colony stimulating factor (GM-CSF), and interferon gamma (INF-gamma). (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1170 |
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| Accepted_Therapeutic_Use_For |
Skin metastasis of breast cancer |
|
| CAS_Registry |
58066-85-6 |
|
| Chemical_Formula |
C21H46NO4P |
|
| code |
C1170 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC |
|
| DEFINITION |
An orally- and topically-active alkyl-phosphocholine compound with potential antineoplastic activity. Miltefosine targets cellular membranes, modulating cell membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. As an immunomodulator, miltefosine stimulates T-cells, macrophages and the expression of interleukin 3 (IL-3), granulocyte-macrophage colony stimulating factor (GM-CSF), and interferon gamma (INF-gamma). (NCI04) |
|
| FDA_UNII_Code |
53EY29W7EC |
|
| FULL_SYN |
n-Hexadecylphosphorylcholine 2-[[(Hexadecycloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium Inner Salt Hexadecylphosphocholine MILTEFOSINE Miltefosine Miltefosina Hexadecyl 2-(N,N,N-trimethylamino)ethyl Phosphate Choline Phosphate Hexadecyl Ester, Hydroxide, Inner Salt Miltefosinum D-18506 Miltefosin Miltex |
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| Is_Value_For_GDC_Property | ||
| label |
Miltefosine |
|
| Legacy Concept Name |
Miltefosine |
|
| Maps_To |
Miltefosine |
|
| NCI_Drug_Dictionary_ID |
41212 |
|
| PDQ_Closed_Trial_Search_ID |
41212 |
|
| PDQ_Open_Trial_Search_ID |
41212 |
|
| Preferred_Name |
Miltefosine |
|
| prefixIRI |
Thesaurus:C1170 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0068006 |
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| subClassOf |