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National Cancer Institute Thesaurus
| Preferred Name | Omacetaxine Mepesuccinate | |
| Synonyms |
Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), [3(R)]- (9CI) homoharringtonine Cephalotaxine, 4-Methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester) Omacetaxine Mepesuccinate OMACETAXINE MEPESUCCINATE Cephalotaxine, 4-Methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester), [3(R)]- (9CI) CGX-635 Ceflatonin HHT Omapro Synribo |
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| Definitions |
A semisynthetic formulation of the cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus with potential antineoplastic activity. Omacetaxine binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. This agent also induces differentiation and apoptosis in some cancer cell types. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1127 |
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| ALT_DEFINITION |
An anticancer drug that belongs to the plant alkaloid family of drugs.
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| CAS_Registry |
26833-87-4
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| Chemical_Formula |
C29H39NO9
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| code |
C1127
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC
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|
| DEFINITION |
A semisynthetic formulation of the cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus with potential antineoplastic activity. Omacetaxine binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. This agent also induces differentiation and apoptosis in some cancer cell types.
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| Display_Name |
Omacetaxine Mepesuccinate
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| FDA_UNII_Code |
6FG8041S5B
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| FULL_SYN |
Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), [3(R)]- (9CI) homoharringtonine Cephalotaxine, 4-Methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester) Omacetaxine Mepesuccinate OMACETAXINE MEPESUCCINATE Cephalotaxine, 4-Methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester), [3(R)]- (9CI) CGX-635 Ceflatonin HHT Omapro Synribo
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Omacetaxine Mepesuccinate
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|
| Legacy Concept Name |
Homoharringtonine
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|
| Maps_To |
Omacetaxine Mepesuccinate
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| NCI_Drug_Dictionary_ID |
39476
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| NSC Number |
141633
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| PDQ_Closed_Trial_Search_ID |
39476
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| PDQ_Open_Trial_Search_ID |
39476
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| Preferred_Name |
Omacetaxine Mepesuccinate
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| prefixIRI |
Thesaurus:C1127
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0062941
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| subClassOf |
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