loading...| Preferred Name | Fludrocortisone Acetate | |
| Synonyms |
Fludrocortisone Acetate FLUDROCORTISONE ACETATE Florinef acetate Fludrocortisone acetate Florinef Acetate Florinef |
|
| Definitions |
The acetate salt of a synthetic fluorinated corticosteroid with antiinflammatory and antiallergic activities. As a glucocorticoid-receptor agonist, fludrocortisone binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1103 |
|
| CAS_Registry |
514-36-3 |
|
| Chemical_Formula |
C23H31FO6 |
|
| code |
C1103 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The acetate salt of a synthetic fluorinated corticosteroid with antiinflammatory and antiallergic activities. As a glucocorticoid-receptor agonist, fludrocortisone binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney. |
|
| FDA_UNII_Code |
V47IF0PVH4 |
|
| FULL_SYN |
Fludrocortisone Acetate FLUDROCORTISONE ACETATE Florinef acetate Fludrocortisone acetate Florinef Acetate Florinef |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Fludrocortisone Acetate |
|
| Legacy Concept Name |
Fludrocortisone |
|
| NCI_Drug_Dictionary_ID |
39243 |
|
| NSC Number |
15186 |
|
| PDQ_Closed_Trial_Search_ID |
39243 |
|
| PDQ_Open_Trial_Search_ID |
39243 |
|
| Preferred_Name |
Fludrocortisone Acetate |
|
| prefixIRI |
Thesaurus:C1103 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0616274 |
|
| subClassOf |