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National Cancer Institute Thesaurus
| Preferred Name | Pembrolizumab | |
| Synonyms |
Pembrolizumab Lambrolizumab Pembrolizumab Biosimilar BCD-201 pembrolizumab Immunoglobulin G4, Anti-(Human Programmed Cell Death 1); Humanized Mouse Monoclonal (228-L-proline(H10-S>P))gamma 4 Heavy Chain (134-218')-disulfide with Humanized Mouse Monoclonal Kappa Light Chain Dimer (226-226'':229-229'')-bisdisulfide PEMBROLIZUMAB BCD-201 Keytruda MK-3475 SCH 900475 |
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| Definitions |
A humanized monoclonal immunoglobulin (Ig) G4 antibody directed against human cell surface receptor PD-1 (programmed death-1 or programmed cell death-1) with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, pembrolizumab binds to PD-1, an inhibitory signaling receptor expressed on the surface of activated T cells, and blocks the binding to and activation of PD-1 by its ligands, which results in the activation of T-cell-mediated immune responses against tumor cells. The ligands for PD-1 include programmed cell death ligand 1 (PD-L1), overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on APCs. Activated PD-1 negatively regulates T-cell activation and plays a key role in in tumor evasion from host immunity. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C106432 |
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| Accepted_Therapeutic_Use_For |
soft tissue sarcoma (STS) postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer; recurrent or metastatic head and neck squamous cell carcinoma (HNSCC); metastatic non-small cell lung cancer (NSCLC) whose tumors express PD-L1; unresectable or metastatic melanoma or melanoma with involvement of lymph node(s) following complete resection; metastatic small cell lung cancer (SCLC); advanced renal cell carcinoma (RCC); recurrent or metastatic cervical cancer; refractory primary mediastinal large B-cell lymphoma (PMBCL); urothelial cancer; hepatocellular carcinoma (HCC); recurrent locally advanced or metastatic Merkel cell carcinoma (MCC)
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| CAS_Registry |
1374853-91-4
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| code |
C106432
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192234 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 |
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| Contributing_Source |
CTRP FDA GDC HemOnc OORO PCDC
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| DEFINITION |
A humanized monoclonal immunoglobulin (Ig) G4 antibody directed against human cell surface receptor PD-1 (programmed death-1 or programmed cell death-1) with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, pembrolizumab binds to PD-1, an inhibitory signaling receptor expressed on the surface of activated T cells, and blocks the binding to and activation of PD-1 by its ligands, which results in the activation of T-cell-mediated immune responses against tumor cells. The ligands for PD-1 include programmed cell death ligand 1 (PD-L1), overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on APCs. Activated PD-1 negatively regulates T-cell activation and plays a key role in in tumor evasion from host immunity.
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| Display_Name |
Pembrolizumab
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| FDA_UNII_Code |
DPT0O3T46P
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| FULL_SYN |
Pembrolizumab Lambrolizumab Pembrolizumab Biosimilar BCD-201 pembrolizumab Immunoglobulin G4, Anti-(Human Programmed Cell Death 1); Humanized Mouse Monoclonal (228-L-proline(H10-S>P))gamma 4 Heavy Chain (134-218')-disulfide with Humanized Mouse Monoclonal Kappa Light Chain Dimer (226-226'':229-229'')-bisdisulfide PEMBROLIZUMAB BCD-201 Keytruda MK-3475 SCH 900475
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| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Pembrolizumab
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| Maps_To |
Pembrolizumab
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| NCI_Drug_Dictionary_ID |
695789
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| PDQ_Closed_Trial_Search_ID |
695789
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| PDQ_Open_Trial_Search_ID |
695789
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| Preferred_Name |
Pembrolizumab
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| prefixIRI |
Thesaurus:C106432
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| UMLS_CUI |
C3658706
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| subClassOf |
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