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National Cancer Institute Thesaurus
| Preferred Name | Cyproterone Acetate | |
| Synonyms |
3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 17-(Acetyloxy)-6-chloro-1,2-dihydro-, (1beta,2beta)- Cyproterone Acetate Chloro-6-hydroxy-17 Alpha Methylene-1 Alpha, 2 Alpha Pregnadiene-4,6 Dione-3, 20 Acetate Cyproteronazetat Andro-Diane Cyproterone acetate 6-Chloro-1b,2b-dihydro-17a-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione Acetate CYPROTERONE ACETATE Cyproteroni Acetas cyproterone acetate Androcur CyPat Cyprone Cyprostat Diane Dianette SH 714 SH-714 |
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| Definitions |
The acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1059 |
|
| ALT_DEFINITION |
A synthetic hormone being studied for treatment of hot flashes in men with prostate cancer who have had both testicles removed by surgery.
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|
| CAS_Registry |
427-51-0
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|
| CHEBI_ID |
CHEBI:50743
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|
| Chemical_Formula |
C24H29ClO4
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|
| code |
C1059
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
FDA GDC HemOnc
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|
| DEFINITION |
The acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels.
|
|
| FDA_UNII_Code |
4KM2BN5JHF
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|
| FULL_SYN |
3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 17-(Acetyloxy)-6-chloro-1,2-dihydro-, (1beta,2beta)- Cyproterone Acetate Chloro-6-hydroxy-17 Alpha Methylene-1 Alpha, 2 Alpha Pregnadiene-4,6 Dione-3, 20 Acetate Cyproteronazetat Andro-Diane Cyproterone acetate 6-Chloro-1b,2b-dihydro-17a-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione Acetate CYPROTERONE ACETATE Cyproteroni Acetas cyproterone acetate Androcur CyPat Cyprone Cyprostat Diane Dianette SH 714 SH-714
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Cyproterone Acetate
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|
| Legacy Concept Name |
Cyproterone_Acetate
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|
| Maps_To |
Cyproterone Acetate
|
|
| NCI_Drug_Dictionary_ID |
39203
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| NSC Number |
81430
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| PDQ_Closed_Trial_Search_ID |
39203
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| PDQ_Open_Trial_Search_ID |
39203
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|
| Preferred_Name |
Cyproterone Acetate
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|
| prefixIRI |
Thesaurus:C1059
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0056855
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| subClassOf |
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