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National Cancer Institute Thesaurus
| Preferred Name | Pegfilgrastim Biosimilar LA-EP2006 | |
| Synonyms |
Pegfilgrastim Biosimilar LA-EP2006 LA-EP2006 |
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| Definitions |
A biosimilar of pegfilgrastim, a long-acting pegylated form of recombinant human granulocyte colony-stimulating factor (G-CSF) filgrastim, with hematopoietic activity. In a similar manner to G-CSF, pegfilgrastim biosimilar LA-EP2006 binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Therefore, this agent may prevent the incidence and shorten the duration of chemotherapy-induced neutropenia. Conjugation of the cytokine with a branched polyethylene glycol molecule significantly increases this agent's therapeutic half-life compared to filgrastim. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104005 |
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| code |
C104005
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| Concept_In_Subset | ||
| DEFINITION |
A biosimilar of pegfilgrastim, a long-acting pegylated form of recombinant human granulocyte colony-stimulating factor (G-CSF) filgrastim, with hematopoietic activity. In a similar manner to G-CSF, pegfilgrastim biosimilar LA-EP2006 binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Therefore, this agent may prevent the incidence and shorten the duration of chemotherapy-induced neutropenia. Conjugation of the cytokine with a branched polyethylene glycol molecule significantly increases this agent's therapeutic half-life compared to filgrastim.
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| FULL_SYN |
Pegfilgrastim Biosimilar LA-EP2006 LA-EP2006
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| label |
Pegfilgrastim Biosimilar LA-EP2006
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| NCI_Drug_Dictionary_ID |
724518
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| NCI_META_CUI |
CL433964
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| PDQ_Closed_Trial_Search_ID |
724518
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| PDQ_Open_Trial_Search_ID |
724518
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| Preferred_Name |
Pegfilgrastim Biosimilar LA-EP2006
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| prefixIRI |
Thesaurus:C104005
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
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| Mapping To | Ontology | Source |
|---|---|---|
| http://purl.bioontology.org/ontology/PDQ/CDR0000724518 | PDQ | LOOM |
| http://purl.obolibrary.org/obo/NCIT_C104005 | BERO | LOOM |
| http://purl.bioontology.org/ontology/PDQ/CDR0000724518 | PDQ | LOOM |