loading...| Preferred Name |
Piritrexim |
|
| Synonyms |
6-((2,5-Dimethoxyphenyl)methyl)-5-methylpyrido(2,3-d)pyrimidine-2,4-diamine 2,4-Diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine 6-[(2,5-Dimethoxyphenyl)methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine BW 301U BW-301U PIRITREXIM Piritrexim piritrexim |
|
| Definitions |
A synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties. Piritrexim inhibits the enzyme dihydrofolate reductase enzyme, thereby disrupting folate metabolism and DNA synthesis and cell division. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1031 |
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| ALT_DEFINITION |
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called folate antagonists. |
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| CAS_Registry |
72732-56-0 |
|
| Chemical_Formula |
C17H19N5O2 |
|
| code |
C1031 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC |
|
| DEFINITION |
A synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties. Piritrexim inhibits the enzyme dihydrofolate reductase enzyme, thereby disrupting folate metabolism and DNA synthesis and cell division. (NCI04) |
|
| FDA_UNII_Code |
MK2A783ZUT |
|
| FULL_SYN |
6-((2,5-Dimethoxyphenyl)methyl)-5-methylpyrido(2,3-d)pyrimidine-2,4-diamine 2,4-Diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine 6-[(2,5-Dimethoxyphenyl)methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine BW 301U BW-301U PIRITREXIM Piritrexim piritrexim |
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| Has_Salt_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Piritrexim |
|
| Legacy Concept Name |
Piritrexim |
|
| Maps_To |
Piritrexim |
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| NCI_Drug_Dictionary_ID |
40070 |
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| PDQ_Closed_Trial_Search_ID |
40070 |
|
| PDQ_Open_Trial_Search_ID |
40070 |
|
| Preferred_Name |
Piritrexim |
|
| prefixIRI |
Thesaurus:C1031 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0054332 |
|
| subClassOf |