loading...| Preferred Name |
Lipopolysaccharide |
|
| Synonyms |
Lipopolysaccharide LPS |
|
| Definitions |
An endotoxin and biologically active component of the Gram-negative bacterial cell wall that is a Toll-like receptor 4 (TLR4) agonist with potential immunostimulatory activity. Upon internalization, lipopolysaccharide (LPS) activates TLR4 which in turn activates the NFkappaB pathway, in addition to mitogen-activated protein kinases signaling pathways. This leads to the release of proinflammatory cytokines and stimulates an innate immune response against vaccine antigens. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101788 |
|
| CHEBI_ID |
CHEBI:16412 |
|
| code |
C101788 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 |
|
| Contributing_Source |
CTRP |
|
| DEFINITION |
An endotoxin and biologically active component of the Gram-negative bacterial cell wall that is a Toll-like receptor 4 (TLR4) agonist with potential immunostimulatory activity. Upon internalization, lipopolysaccharide (LPS) activates TLR4 which in turn activates the NFkappaB pathway, in addition to mitogen-activated protein kinases signaling pathways. This leads to the release of proinflammatory cytokines and stimulates an innate immune response against vaccine antigens. |
|
| Display_Name |
Lipopolysaccharide |
|
| FULL_SYN |
Lipopolysaccharide LPS |
|
| label |
Lipopolysaccharide |
|
| NCI_Drug_Dictionary_ID |
732862 |
|
| PDQ_Closed_Trial_Search_ID |
732862 |
|
| PDQ_Open_Trial_Search_ID |
732862 |
|
| Preferred_Name |
Lipopolysaccharide |
|
| prefixIRI |
Thesaurus:C101788 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0023810 |
|
| subClassOf |