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Myocardial Infarction Ontology
Last uploaded:
December 18, 2024
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| Preferred Name | lepirudin | |
| Synonyms |
recombinant hirudin r-hirudin refludan |
|
| Definitions |
A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and inactivates thrombin, producing dose-dependent increases in the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The mechanism of action of this agent is independent of antithrombin III and is not inhibited by platelet factor 4. Natural hirudin, a family of highly homologous isopolypeptides, is produced in trace amounts by the leech Hirudo medicinalis. [url:http://purl.obolibrary.org/obo/NCIT_C1839] |
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| ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02637 |
|
| definition |
A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and inactivates thrombin, producing dose-dependent increases in the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The mechanism of action of this agent is independent of antithrombin III and is not inhibited by platelet factor 4. Natural hirudin, a family of highly homologous isopolypeptides, is produced in trace amounts by the leech Hirudo medicinalis. [url:http://purl.obolibrary.org/obo/NCIT_C1839]
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|
| label |
lepirudin
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|
| MIO_ID |
MIO:02637
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|
| prefLabel |
lepirudin
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|
| reference |
NCIT:C1839
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|
| synonyms |
recombinant hirudin r-hirudin refludan
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|
| subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02147 |
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