Preferred Name |
ramipril |
|
Synonyms |
altace |
|
Definitions |
A prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. [url:http://purl.obolibrary.org/obo/NCIT_C29411] |
|
ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02626 |
|
definition |
A prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. [url:http://purl.obolibrary.org/obo/NCIT_C29411] |
|
label |
ramipril |
|
MIO_ID |
MIO:02626 |
|
prefLabel |
ramipril |
|
reference |
NCIT:C29411 |
|
synonyms |
altace |
|
subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02115 |