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Myocardial Infarction Ontology
| Preferred Name | enalapril | |
| Synonyms |
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| Definitions |
A dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. [url:http://purl.obolibrary.org/obo/NCIT_C62027] |
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| ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02621 |
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| definition |
A dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. [url:http://purl.obolibrary.org/obo/NCIT_C62027]
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| label |
enalapril
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| MIO_ID |
MIO:02621
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| prefLabel |
enalapril
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| reference |
UMLS:C0014025 NCIT:C62027 CHEBI:4784
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| subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02115 |
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