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Myocardial Infarction Ontology
Preferred Name | cilazapril monohydrate | |
Synonyms |
(1S,9S)-9-(((S)-1-Carboxy-3-phenylpropyl)amino)octahydro-10-oxo-6H-pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid 9-ethyl ester monohydrate Ro 31-2848 monohydrate cilazapril |
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Definitions |
A pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. [url:http://purl.obolibrary.org/obo/NCIT_C76133] |
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ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02620 |
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definition |
A pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. [url:http://purl.obolibrary.org/obo/NCIT_C76133]
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label |
cilazapril monohydrate
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MIO_ID |
MIO:02620
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prefLabel |
cilazapril monohydrate
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reference |
UMLS:C0055723 NCIT:C76133
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synonyms |
(1S,9S)-9-(((S)-1-Carboxy-3-phenylpropyl)amino)octahydro-10-oxo-6H-pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid 9-ethyl ester monohydrate Ro 31-2848 monohydrate cilazapril
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subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02115 |
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