Myocardial Infarction Ontology

Last uploaded: December 18, 2024
Preferred Name

isosorbide dinitrate
Synonyms

isordil

Definitions

The dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide dinitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide dinitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. [url:http://purl.obolibrary.org/obo/NCIT_C29134]

ID

http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02172

definition

The dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide dinitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide dinitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. [url:http://purl.obolibrary.org/obo/NCIT_C29134]

label

isosorbide dinitrate

MIO_ID

MIO:02172

prefLabel

isosorbide dinitrate

reference

UMLS:C0022252

NCIT:C29134

synonyms

isordil

subClassOf

http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01105

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Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_6061 DRON LOOM
http://purl.obolibrary.org/obo/NCIT_C29134 BERO LOOM
http://purl.bioontology.org/ontology/MESH/D007548 MESH LOOM
https://go.drugbank.com/drugs/DB00883 MDM LOOM
http://purl.bioontology.org/ontology/ATC/C01DA08 ATC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015778 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/RXNORM/6058 RXNORM LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29134 NCIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007548 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#IsosorbideDinitrate GALEN LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146183 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4017825 VANDF LOOM
http://bmi.utah.edu/ontologies/hfontology/C0022252 HFO LOOM
http://purl.bioontology.org/ontology/SNMI/C-81550 SNMI LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146183 OCVDAE LOOM
http://www.drugbank.ca/drugs/DB00883 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0022252 OCHV LOOM
http://purl.bioontology.org/ontology/RCD/bl2.. RCD LOOM
http://purl.obolibrary.org/obo/CHEBI_6061 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6061 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_6061 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6061 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6061 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_6061 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_6061 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6061 NIFSTD LOOM
http://purl.bioontology.org/ontology/NDDF/000688 NDDF LOOM
http://purl.obolibrary.org/obo/OMIT_0008662 OMIT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6968 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D09.853.813.480.500 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.033.800.813.480.500 RH-MESH LOOM
http://purl.jp/bio/4/id/200906043642064379 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/C05AE02 ATC LOOM
http://purl.obolibrary.org/obo/MESH_D007548 BERO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387332007 SNOMEDCT LOOM