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Myocardial Infarction Ontology
| Preferred Name | dofetilide | |
| Synonyms |
beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl)- tikosyn |
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| Definitions |
A sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter. [url:http://purl.obolibrary.org/obo/NCIT_C47499] |
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| ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02165 |
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| definition |
A sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter. [url:http://purl.obolibrary.org/obo/NCIT_C47499]
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| label |
dofetilide
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| MIO_ID |
MIO:02165
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| prefLabel |
dofetilide
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| reference |
UMLS:C0114771 NCIT:C47499 CHEBI:4681
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| synonyms |
beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl)- tikosyn
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| subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01100 |
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