Preferred Name |
rosiglitazone |
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Synonyms |
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Definitions |
An agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic and anti-inflammatory activities. In addition to its selective affinity for peroxisome proliferator-activated receptor (PPAR) gamma and its ability to lower blood glucose levels, rosiglitazone also exerts anti-inflammatory activity through its ability to inhibit nuclear factor-kappaB (NF-KB) activity and increase I-kappaB levels. In addition, rosiglitazone may cause fluid retention and may worsen congestive heart failure. This agent is also associated with an increased risk of heart attacks. [url:http://purl.obolibrary.org/obo/NCIT_C62076] |
|
ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02131 |
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definition |
An agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic and anti-inflammatory activities. In addition to its selective affinity for peroxisome proliferator-activated receptor (PPAR) gamma and its ability to lower blood glucose levels, rosiglitazone also exerts anti-inflammatory activity through its ability to inhibit nuclear factor-kappaB (NF-KB) activity and increase I-kappaB levels. In addition, rosiglitazone may cause fluid retention and may worsen congestive heart failure. This agent is also associated with an increased risk of heart attacks. [url:http://purl.obolibrary.org/obo/NCIT_C62076] |
|
label |
rosiglitazone |
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MIO_ID |
MIO:02131 |
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prefLabel |
rosiglitazone |
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reference |
NCIT:C62076 |
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subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01070 |