loading...| Preferred Name |
Unfolded Protein Response |
|
| Synonyms |
Response, Unfolded Protein Unfolded Protein Responses |
|
| Definitions |
A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D056811 |
|
| altLabel |
Response, Unfolded Protein Protein Response, Unfolded Protein Responses, Unfolded Responses, Unfolded Protein Unfolded Protein Responses |
|
| AQL |
DE GE IM PH RE |
|
| cui |
C1155342 |
|
| DC |
1 |
|
| definition |
A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS. |
|
| DX |
20100101 |
|
| FX |
D060746 D059865 |
|
| HN |
2010 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000187 |
|
| Inverse of RO |
http://purl.bioontology.org/ontology/MESH/D058767 |
|
| Machine permutation |
2010 |
|
| MDA |
20090706 |
|
| MMR |
20220712 |
|
| MN |
G02.111.660.871.790.600.962 G03.734.871.790.600.850 G02.111.691.600.850 G04.434.500 G05.308.670.600.850 |
|
| notation |
D056811 |
|
| prefLabel |
Unfolded Protein Response |
|
| TERMUI |
T734690 |
|
| TH |
NLM (2010) |
|
| tui |
T043 |
|
| subClassOf |