Medical Subject Headings

Last uploaded: August 28, 2024
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Preferred Name

Integrin alpha Chains
Synonyms

alpha Integrins

Integrins, alpha

Integrin alpha Subunits

alpha Chains, Integrin
Definitions

The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
ID

http://purl.bioontology.org/ontology/MESH/D039001
altLabel

alpha Integrins

Integrins, alpha

Integrin alpha Subunits

alpha Chains, Integrin
AQL

AD AG AI AN BI BL CH CL DE DF GE HI IM IP ME PH RE TU UL
cui

C1136252
DC

1
definition

The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
DX

20030101
HN

2003
Inverse of AQ

http://purl.bioontology.org/ontology/MESH/Q000097

http://purl.bioontology.org/ontology/MESH/Q000096

http://purl.bioontology.org/ontology/MESH/Q000172

http://purl.bioontology.org/ontology/MESH/Q000627

http://purl.bioontology.org/ontology/MESH/Q000648

http://purl.bioontology.org/ontology/MESH/Q000276

http://purl.bioontology.org/ontology/MESH/Q000266

http://purl.bioontology.org/ontology/MESH/Q000378

http://purl.bioontology.org/ontology/MESH/Q000008

http://purl.bioontology.org/ontology/MESH/Q000032

http://purl.bioontology.org/ontology/MESH/Q000037

http://purl.bioontology.org/ontology/MESH/Q000302

http://purl.bioontology.org/ontology/MESH/Q000145

http://purl.bioontology.org/ontology/MESH/Q000737

http://purl.bioontology.org/ontology/MESH/Q000819

http://purl.bioontology.org/ontology/MESH/Q000502

http://purl.bioontology.org/ontology/MESH/Q000187

http://purl.bioontology.org/ontology/MESH/Q000235

http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB

0
Machine permutation

2003
Mapped from

http://purl.bioontology.org/ontology/MESH/C082188

http://purl.bioontology.org/ontology/MESH/C085725

http://purl.bioontology.org/ontology/MESH/C527123

http://purl.bioontology.org/ontology/MESH/C000709215

http://purl.bioontology.org/ontology/MESH/C565999

http://purl.bioontology.org/ontology/MESH/C406210

http://purl.bioontology.org/ontology/MESH/C423602

http://purl.bioontology.org/ontology/MESH/C572269

http://purl.bioontology.org/ontology/MESH/C558437

http://purl.bioontology.org/ontology/MESH/C584572

http://purl.bioontology.org/ontology/MESH/C063493

http://purl.bioontology.org/ontology/MESH/C000727154

http://purl.bioontology.org/ontology/MESH/C084613

http://purl.bioontology.org/ontology/MESH/C093856

http://purl.bioontology.org/ontology/MESH/C000610207

http://purl.bioontology.org/ontology/MESH/C410954

http://purl.bioontology.org/ontology/MESH/C579157

http://purl.bioontology.org/ontology/MESH/C121535

http://purl.bioontology.org/ontology/MESH/C091367

http://purl.bioontology.org/ontology/MESH/C406812

http://purl.bioontology.org/ontology/MESH/C000621953
MDA

20020702
MMR

20130709
MN

D12.776.543.750.705.408.100
notation

D039001
prefLabel

Integrin alpha Chains
TERMUI

T490021

T486340

T493845
TH

NLM (2003)
tui

T116

T123
subClassOf

http://purl.bioontology.org/ontology/MESH/D016023
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