loading...| Preferred Name | Integrins | |
| Synonyms |
Integrin |
|
| Definitions |
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors (RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D016023 |
|
| altLabel |
Integrin |
|
| AN |
prefer specifics |
|
| AQL |
AD AG AI AN BI BL CF CH CL DE DF GE HI IM IP ME PH RE TU UL |
|
| cui |
C0021701 |
|
| DC |
1 |
|
| definition |
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors (RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation. |
|
| DX |
19900101 |
|
| FX |
D015815 |
|
| HN |
90 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000187 |
|
| Inverse of RB |
0 |
|
| Inverse of RO | ||
| Machine permutation |
90 |
|
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C082908 http://purl.bioontology.org/ontology/MESH/C113256 http://purl.bioontology.org/ontology/MESH/C530829 http://purl.bioontology.org/ontology/MESH/C000632233 http://purl.bioontology.org/ontology/MESH/C118346 http://purl.bioontology.org/ontology/MESH/C000631264 http://purl.bioontology.org/ontology/MESH/C000621978 http://purl.bioontology.org/ontology/MESH/C541973 http://purl.bioontology.org/ontology/MESH/C521951 http://purl.bioontology.org/ontology/MESH/C075596 http://purl.bioontology.org/ontology/MESH/C000619308 http://purl.bioontology.org/ontology/MESH/C073878 http://purl.bioontology.org/ontology/MESH/C403414 http://purl.bioontology.org/ontology/MESH/C467800 http://purl.bioontology.org/ontology/MESH/C071777 |
|
| MDA |
19890707 |
|
| MMR |
20210630 |
|
| MN |
D12.776.543.750.705.408 |
|
| notation |
D016023 |
|
| prefLabel |
Integrins |
|
| TERMUI |
T047571 T000996175 |
|
| TH |
NLM (1990) NLM (2021) |
|
| tui |
T116 T129 T192 |
|
| subClassOf |