loading...| Preferred Name | Calcineurin | |
| Synonyms |
Phosphatase 3, Protein Calcineurin B Protein Phosphatase-2B Protein Phosphatase 3 Protein Phosphatase 3 Catalytic Subunit Protein Phosphatase 3 Regulatory Subunit Calcineurin A Protein Phosphatase 2B |
|
| Definitions |
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D019703 |
|
| altLabel |
Phosphatase 3, Protein Calcineurin B Protein Phosphatase-2B Protein Phosphatase 3 Protein Phosphatase 3 Catalytic Subunit Protein Phosphatase 3 Regulatory Subunit Calcineurin A Protein Phosphatase 2B |
|
| AQL |
AD AE AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR |
|
| cui |
C0255499 C0259728 C0054450 |
|
| DC |
1 |
|
| definition |
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes. |
|
| DX |
19980101 |
|
| EC |
antagonists & inhibitors:Calcineurin Inhibitors |
|
| HN |
98; see CALCINEURIN (NM) 1987-97 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
| Inverse of RB |
EC 3.1.3.16 0 |
|
| Machine permutation |
98; CALCINEURIN was indexed under PHOSPHOPROTEIN PHOSPHATASE 1988-97 & CALMODULIN-BINDING PROTEINS 1986-97; CALCINEURIN B (now CALCINEURIN) was indexed under CALCIUM-BINDING PROTEINS 1994-97 |
|
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C071056 http://purl.bioontology.org/ontology/MESH/C000602854 http://purl.bioontology.org/ontology/MESH/C503672 http://purl.bioontology.org/ontology/MESH/C585092 http://purl.bioontology.org/ontology/MESH/C000628549 http://purl.bioontology.org/ontology/MESH/C070394 http://purl.bioontology.org/ontology/MESH/C070393 http://purl.bioontology.org/ontology/MESH/C000602830 http://purl.bioontology.org/ontology/MESH/C585177 http://purl.bioontology.org/ontology/MESH/C525676 http://purl.bioontology.org/ontology/MESH/C525673 http://purl.bioontology.org/ontology/MESH/C525674 http://purl.bioontology.org/ontology/MESH/C525675 http://purl.bioontology.org/ontology/MESH/C569328 http://purl.bioontology.org/ontology/MESH/C557393 |
|
| MDA |
19970620 |
|
| MMR |
20210520 |
|
| MN |
D08.811.277.352.650.625.150 D12.776.476.559.150 D12.644.360.087 |
|
| notation |
D019703 |
|
| prefLabel |
Calcineurin |
|
| TERMUI |
T058607 T058603 T712674 T058606 T058604 T712675 T712676 |
|
| TH |
NLM (2009) NLM (1998) |
|
| tui |
T116 T126 T123 |
|
| subClassOf |