loading...| Preferred Name |
Apolipoprotein A-I |
|
| Synonyms |
Apolipoprotein A-1 |
|
| Definitions |
The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D016632 |
|
| altLabel |
Apolipoprotein A-1 Proapolipoprotein AI Pro-Apo A-I Apo A-I ApoA-I Apolipoprotein AI Propeptide Apo AI Apo A I Isoproteins ApoA-1 Apolipoprotein AI Apolipoprotein A I Isoprotein 4 Pro-Apolipoprotein A-I Apo A-I Isoproteins Pro Apo A I Apolipoprotein A-I Isoproteins Apolipoprotein A1 Pro Apolipoprotein A I Apolipoprotein A I Apolipoprotein A-I Isoprotein-4 Apolipoprotein A 1 Apolipoprotein A-I Isoprotein-2 Apolipoprotein A I Isoproteins Apolipoprotein A I Isoprotein 2 Apo A1 Apo A-1 |
|
| AQL |
AD AE AG AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR |
|
| cui |
C0052179 C0103832 C0071993 C0085201 C0103831 |
|
| DC |
1 |
|
| definition |
The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE. Variants of apolipoprotein A-I. They include secreted propeptide form (isoprotein 2), the converted plasma form (isoprotein-4), and those with various substitutions or deletions. |
|
| DX |
19920101 |
|
| HN |
1992 (1974); for PRO-APOLIPOPROTEIN A-I (NM) use APOLIPOPROTEINS A & PROTEIN PRECURSORS 1983-2006; for APOLIPOPROTEIN A-I ISOPROTEINS (NM) use APOLIPOPROTEINS A 1980-2006 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
| Inverse of RB |
0 |
|
| Machine permutation |
1992; APOLIPOPROTEIN A-I was indexed under APOLIPOPROTEINS A 1985-1991, under APOLIPOPROTEINS 1979-1984 & under APOPROTEINS 1974-1978; PRO-APOLIPOPROTEIN A-I was indexed under APOLIPOPROTEINS A & PROTEIN PRECURSORS 1983-2006; APOLIPOPROTEIN A-I ISOPROTEINS was indexed under APOLIPOPROTEINS A 1980-2006 |
|
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C000706970 http://purl.bioontology.org/ontology/MESH/C041414 http://purl.bioontology.org/ontology/MESH/C465468 http://purl.bioontology.org/ontology/MESH/C426725 http://purl.bioontology.org/ontology/MESH/C405602 http://purl.bioontology.org/ontology/MESH/C474616 http://purl.bioontology.org/ontology/MESH/C063686 http://purl.bioontology.org/ontology/MESH/C505693 http://purl.bioontology.org/ontology/MESH/C080631 http://purl.bioontology.org/ontology/MESH/C095606 http://purl.bioontology.org/ontology/MESH/C114042 http://purl.bioontology.org/ontology/MESH/C043360 |
|
| MDA |
19910124 |
|
| MMR |
20060705 |
|
| MN |
D12.776.070.400.200.100 D12.776.521.120.200.100 D10.532.091.200.100 |
|
| notation |
D016632 |
|
| prefLabel |
Apolipoprotein A-I |
|
| TERMUI |
T049788 T147574 T117285 T117286 T049787 T049793 T147577 T049789 T117282 T049790 T147576 T117287 T049784 T147575 T049791 T049785 T049792 T049786 |
|
| TH |
NLM (1992) NLM (2007) |
|
| tui |
T116 T123 |
|
| subClassOf |