| Preferred Name |
Dideoxyadenosine
|
|
| Synonyms |
Adenosine, 2',3'-dideoxy-
2',3'-Dideoxyadenosine
ddA (Antiviral)
2',3' Dideoxyadenosine
|
|
| Definitions |
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.
|
|
| ID |
http://purl.bioontology.org/ontology/MESH/D016048
|
|
| altLabel |
Adenosine, 2',3'-dideoxy- 2',3'-Dideoxyadenosine ddA (Antiviral) 2',3' Dideoxyadenosine
|
|
| AN |
an antiviral; inhibits HIV replication
|
|
| AQL |
AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
|
|
| cui |
C0012131
|
|
| DC |
1
|
|
| definition |
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.
|
|
| DX |
19900101
|
|
| HN |
90
|
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
|
|
| Inverse of RB |
4Q86AH641A
|
|
| isa |
http://purl.bioontology.org/ontology/MESH/D000963 http://purl.bioontology.org/ontology/MESH/D000998
|
|
| Machine permutation |
90
|
|
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C071312 http://purl.bioontology.org/ontology/MESH/C492871 http://purl.bioontology.org/ontology/MESH/C569661 http://purl.bioontology.org/ontology/MESH/C021008 http://purl.bioontology.org/ontology/MESH/C095412 http://purl.bioontology.org/ontology/MESH/C055320 http://purl.bioontology.org/ontology/MESH/C113650 http://purl.bioontology.org/ontology/MESH/C113651 http://purl.bioontology.org/ontology/MESH/C113652 http://purl.bioontology.org/ontology/MESH/C000723098 http://purl.bioontology.org/ontology/MESH/C418262 http://purl.bioontology.org/ontology/MESH/C000631408 http://purl.bioontology.org/ontology/MESH/C090031 http://purl.bioontology.org/ontology/MESH/C010848 http://purl.bioontology.org/ontology/MESH/C065950 http://purl.bioontology.org/ontology/MESH/C075923 http://purl.bioontology.org/ontology/MESH/C067988 http://purl.bioontology.org/ontology/MESH/C000723103 http://purl.bioontology.org/ontology/MESH/C445119 http://purl.bioontology.org/ontology/MESH/C052692 http://purl.bioontology.org/ontology/MESH/C055319 http://purl.bioontology.org/ontology/MESH/C073072 http://purl.bioontology.org/ontology/MESH/C055502 http://purl.bioontology.org/ontology/MESH/C055503 http://purl.bioontology.org/ontology/MESH/C055504 http://purl.bioontology.org/ontology/MESH/C059400 http://purl.bioontology.org/ontology/MESH/C527071 http://purl.bioontology.org/ontology/MESH/C106538 http://purl.bioontology.org/ontology/MESH/C483489 http://purl.bioontology.org/ontology/MESH/C483488
|
|
| MDA |
19890714
|
|
| MMR |
20160531
|
|
| MN |
D03.633.100.759.590.138.325.105 D13.570.230.500.105 D13.570.583.138.325.105 D13.570.230.229.105
|
|
| notation |
D016048
|
|
| PA |
D000998 D000963
|
|
| prefLabel |
Dideoxyadenosine
|
|
| RR |
4097-22-7 (Dideoxyadenosine)
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|
| TERMUI |
T047682 T047680 T047681
|
|
| TH |
NLM (1990) FDA SRS (2014)
|
|
| tui |
T114 T121
|
|
| subClassOf |
http://purl.bioontology.org/ontology/MESH/D015224 http://purl.bioontology.org/ontology/MESH/D003839
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