loading...| Preferred Name |
Teniposide |
|
| Synonyms |
NSC 122819 Vumon NSC122819 VM-26 Demethyl Epipodophyllotoxin Thenylidine Glucoside VM26 Teniposide, (5a alpha,9 alpha(S*))-Isomer NSC-122819 VM 26 Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-((4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl)oxy)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))- |
|
| Definitions |
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D013713 |
|
| altLabel |
NSC 122819 Vumon NSC122819 VM-26 Demethyl Epipodophyllotoxin Thenylidine Glucoside VM26 Teniposide, (5a alpha,9 alpha(S*))-Isomer NSC-122819 VM 26 Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-((4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl)oxy)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))- |
|
| AQL |
AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR |
|
| cui |
C0886917 C0039512 C0728981 C0733482 C0733480 |
|
| DC |
1 |
|
| definition |
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle. |
|
| DX |
19910101 |
|
| HN |
91(81); was see under PODOPHYLLOTOXIN 1981-90; was VM 26 see under PODOPHYLLOTOXIN 1976-80 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
| Inverse of RB |
89301-94-0 957E6438QA 0 |
|
| isa | ||
| LT |
TRD |
|
| Machine permutation |
91; was see under PODOPHYLLOTOXIN 1981-90; was VM 26 see under PODOPHYLLOTOXIN 1976-80 |
|
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C091779 http://purl.bioontology.org/ontology/MESH/C087652 http://purl.bioontology.org/ontology/MESH/C044586 http://purl.bioontology.org/ontology/MESH/C042306 http://purl.bioontology.org/ontology/MESH/C042305 http://purl.bioontology.org/ontology/MESH/C071786 http://purl.bioontology.org/ontology/MESH/C054969 http://purl.bioontology.org/ontology/MESH/C500531 http://purl.bioontology.org/ontology/MESH/C098385 http://purl.bioontology.org/ontology/MESH/C495278 http://purl.bioontology.org/ontology/MESH/C452189 http://purl.bioontology.org/ontology/MESH/C107596 http://purl.bioontology.org/ontology/MESH/C081885 http://purl.bioontology.org/ontology/MESH/C104872 http://purl.bioontology.org/ontology/MESH/C110048 http://purl.bioontology.org/ontology/MESH/C092880 http://purl.bioontology.org/ontology/MESH/C471581 http://purl.bioontology.org/ontology/MESH/C471582 http://purl.bioontology.org/ontology/MESH/C407550 http://purl.bioontology.org/ontology/MESH/C039551 http://purl.bioontology.org/ontology/MESH/C057981 http://purl.bioontology.org/ontology/MESH/C049020 http://purl.bioontology.org/ontology/MESH/C075513 |
|
| MDA |
19750725 |
|
| MMR |
20160701 |
|
| MN |
D09.408.348.800 |
|
| notation |
D013713 |
|
| OL |
use TENIPOSIDE to search VM 26 1976-80 |
|
| PA |
D059005 D000970 |
|
| prefLabel |
Teniposide |
|
| RR |
53956-10-8 (cpd without chiral (R*/S*) notation) 29767-20-2 (Teniposide) 89301-94-0 ((5a alpha,9 alpha(S*))-isomer) |
|
| TERMUI |
T040286 T040285 T040289 T359835 T040287 T040288 |
|
| TH |
US MX NL NLM (1999) FDA SRS (2014) ES UNK (19XX) USAN (1978) INN (19XX) AU BAN (19XX) |
|
| tui |
T109 T121 |
|
| subClassOf |