loading...| Preferred Name | Molindone | |
| Synonyms |
Moban Molindone Hydrochloride 4H-Indol-4-one, 3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)- Hydrochloride, Molindone Monohydrochloride, Molindone Molindone Monohydrochloride |
|
| Definitions |
An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283) |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D008972 |
|
| altLabel |
Moban Molindone Hydrochloride 4H-Indol-4-one, 3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)- Hydrochloride, Molindone Monohydrochloride, Molindone Molindone Monohydrochloride |
|
| AQL |
AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR |
|
| cui |
C0733813 C0282249 C0026388 |
|
| DC |
1 |
|
| definition |
An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283) |
|
| DX |
19910101 |
|
| HN |
91(72); was see under INDOLES 1972-90 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
| Inverse of RB |
RT3Y3QMF8N 1DWS68PNE6 0 |
|
| isa | ||
| LT |
TRD |
|
| Machine permutation |
91; was see under INDOLES 1972-90 |
|
| MDA |
19990101 |
|
| MMR |
20170524 |
|
| MN |
D03.633.100.473.629 |
|
| notation |
D008972 |
|
| PA |
D014150 |
|
| prefLabel |
Molindone |
|
| RR |
7416-34-4 (Molindone) 1DWS68PNE6 15622-65-8 (mono-HCl) |
|
| TERMUI |
T026823 T360236 T026824 T026825 |
|
| TH |
US NLM (1999) USAN (1967) FDA SRS (2014) INN (19XX) USP (19XX) BAN (19XX) |
|
| tui |
T109 T121 |
|
| subClassOf |